PATHOGENICITY FOR MAN 225 



ages of two and twelve years. In investigating the 150 cases occur- 

 ring among the inmates, Schroder and Cooper (1930) 1250 isolated 

 an organism described by them as extremely infective and which 

 they identified as Type V Pneumococcus. All the cases save one oc- 

 curred among the boys, who were in frequent and close contact, the 

 sole exception being a girl who had assembled with the boys in a 

 classroom. 



A series of twelve cases of pneumonia and two of otitis media de- 

 veloping over a period of four months among eighty-seven boys in 

 an orphanage was caused by Pneumococcus of Type I. Strom, 1344 

 who studied the epidemic, reported that the infection was more 

 prevalent among the older boys and, furthermore, that of those 

 coming in contact with the affected boys a third of the number 

 were found to be carriers of the same organism. The strains iso- 

 lated from the patients were more virulent for mice than were those 

 recovered from the carriers. 



Infectious Processes Other Than Pneumonia 



Pneumococcus, during the pneumonic process, may migrate from 

 the seat of infection in the lung to the vascular system and thereby 

 be distributed throughout the body and create localized foci. Or, 

 without the intermediate pulmonary lesion, the organisms may by 

 direct or indirect routes gain access to vulnerable tissues. While, 

 because of the abundant data, it is possible to apportion the guilt 

 to representatives of the different serological types in lobar and 

 bronchopneumonia, a verdict is not so easily pronounced in non- 

 pulmonary infections of pneumococcal origin. Many of the reports 

 appeared before the diversity of types was recognized, and since 

 that era the comparative infrequency of non-pulmonary infections 

 has supplied too few observations to be of any statistical value. 



Meningitis as a complication or sequel of lobar pneumonia had 

 early been reported by Fraenkel, 469 Senger, 1255 Netter, 962 Lance- 

 reaux and Besancon, 778 Gamaleia, 498 Meyer, 895 Ortmann, 10378 and 

 others, but not until the report of Foa and Bordoni-Uffreduzzi 462 



