CHEMOTHERAPY 511 



cerning the effect in combating pneumococcal infections. Iodine in 

 colloidal solution was administered by Murphy 940 to ninety pa- 

 tients ill with pneumonia ; of the ninety, ten died. The report con- 

 tained no account of any in vitro experiments with the solution. 



OTHER MEDICINAL AGENTS 



Many drugs have been subjected to clinical trial, not on the 

 basis of laboratory experiment, but apparently in the hope that 

 some selective action on Pneumococcus might follow their adminis- 

 tration. Reports on epinephrine have come from Puscariu and 

 Nitzulescu, 1113 and on camphor by Rosenthal and Stein 1174 and by 

 Welch and Rueck.* According to Boehncke, 133 the subcutaneous 

 injection of camphor dissolved in oil was able to protect mice and 

 rabbits against intraperitoneal and intravenous inoculation with 

 virulent pneumococci made some hours later. Formaldehyde sul- 

 foxylate which, according to Rosenthal, 1177 was without pneumo- 

 coccidal action in vitro, nevertheless, when injected subcutaneously 

 into mice at the time of inoculation in three or four-hour doses 

 repeated daily, protected the animals from an otherwise fatal in- 

 fection. Rosenthal, 1176 and Powell and Jamieson 1104 have also pub- 

 lished the results of experiments with the same drug. Schotts- 

 taedt 1249 and physicians of the United Fruit Company have used 

 without laboratory control enemas of potassium permanganate in 

 the treatment of lobar pneumonia with more or less favorable re- 

 sults which, however, indicate no specific action of the agent used. 

 The same may be said for sodium salicylate as reported by Couvey 

 and Popoff. 285 Hexamethyltetramine (Urotropin) was found by 

 Maeji 851 to be capable in a concentration of 1 to 1,000 to 1 to 

 2,000 of killing pneumococci in vitro. 



Any further recital of reports on other therapeutic agents 

 would add nothing of value to the present discussion, which may 

 now be directed to a class of substances possessing markedly spe- 

 cific antagonistic properties against pneumococci. 



* Quoted by Neufeld and Schnitzer. 



