INDEX 



773 



Antigens (cont.) : 

 concentration, 21, 22 

 culture nitrates, 21, 22, 23, 24, 25, 



27, 335-337, 526-527 

 cultures devitalized 



by alcohol and ether, 333, 530 



by antiformin, 333 



by bile salts, 334 



by formalin, 331-332, 531-532 



by formol, 333 



by heat, 327-331, 333, 530, 531, 

 532 



by phenol, 530 



by sodium choleate, 334 



by sodium ricinoleate, 334 



by sodium taurocholate, 334 

 egg white as adjuvant to, 348 

 exudates, 337-338, 527 

 fat-free, 338 



glycerol extracts, 21, 25, 530 

 hemotoxins, 340 

 host response, 351, 427^178 

 injections in antipneumococcic se- 

 rum production, 533-540 

 living organisms, 528-529 

 methods of administering, 340-351 

 pancreatic extracts, 335 

 Pneumocholin, 334, 483 

 polysaccharides, 251, 255, 283, 290, 



292, 344-345, 349, 448 

 residue, 241 

 rough and smooth strains, 130, 328, 



344 

 sensitized pneumococci, 335 

 sputum, 21 



standardization, 331, 532-533 

 synthetic, 411 

 tissue extracts, 337-338 

 toxins, 93, 95, 338-340 

 virulence of cultures, 25, 326-327, 



524r-526 

 Antihemotoxin(s). See Antitoxin 

 Antiopsonins 



A substance, 400-401 

 antiphagin, 398 



capsular polysaccharide, 399, 400 

 Impedin, 399 



Antipneumococcic serum, production, 



522-597 

 antigens, selection and standardiza- 

 tion. See Antigens 

 avian, 545 

 bleedings, 540-543 



period of immunization prior to, 

 540-542 

 blood, amount drawn, 542 

 bottling, 596 



bulk sterility and potency tests, 590 

 chill-producing factors, 559-563 

 definition of unit, 586 

 desiccation, 559 



diagnostic serum, 592-596, 663-664 

 dispensing and labeling, 590-591 

 filtration, 589 

 final processing, 589-592 

 from asses, 522 

 from cows, 522 

 from goats, 522 

 from horses. See Horse(s) 

 from rabbits. See Rabbit(s) 

 governmental regulation, 591 



British Statutory Rules and Or- 

 ders, 592 



British Therapeutic Substances 

 Act, 592 



National Institute of Health, 567, 

 592 



United States Hygienic Labora- 

 tory, 567 

 identity and safety tests, 591 

 in vitro tests, 580-584 

 injections of antigen, 533-540 



dosage, 534-535 



reactions of horse, 538-540 



route, 533-534 



spacing of doses, 535-538 

 inorganic solids, 556-557 

 labeling, 590-591, 596 

 methods of concentration, biologi- 

 cal, 547-548 

 methods of concentration, chemical, 

 548-556 



alcohol precipitation, 553-554 



ammonium sulfate, 548-549 



carbon dioxide, 553 



