774 



INDEX 



Antipneumococcic serum (cont.): 

 methods of concentration (cont.) : 

 dialysis, 550 



dilution with water, 550-553 

 dissociation of specific precipi- 

 tate, 554 

 metallic salts, 555 

 sodium chloride, 553 

 sodium sulfate, 549-550 

 ultracentrifugation, 556 

 ultrafiltration, 555 

 unsolved problems, 620-621 

 mouse protection test. See Potency 



tests 

 period of immunization prior to 



bleeding, 540-542 

 physical properties, 556-559 

 polyvalent serum, 545-547 

 potency tests. See Potency tests 

 preservatives, 557-559, 588-589, 596 

 reaction of the product, 557 

 records, 591 



safety tests, 587-589, 591 

 sterility tests on final containers, 



591 

 therapeutic tests, 576-580 

 total solids, 556, 589 

 unconcentrated vs. concentrated, 



543-545 

 unit defined, 28, 568, 586-587 

 yield of serum, 542-543 

 Anti-R bodies 



in swine serum, 155 

 Anti-R serum, effect on variants, 154 

 Antitoxin (s), 85, 86, 96, 99, 339-340, 

 383-386, 561, 579 

 antihemotoxin, 85, 382-383 

 potency tests on, 579, 581 

 Antivirus 



as antigen, 336-337, 346 

 effect on virulence of Pneumo- 

 coccus, 337 

 Appendicitis, Pneumococcus in, 226 

 Aromatic amines, peroxide formation, 



74 

 Arthritis, Pneumococcus in, 226 

 Ass(es), immune serum from, 27, 522 



Aureola. See Capsule of Pneumo- 

 coccus 



Autolysates 



lung-toxic principles, 98 

 necrotizing principle, 92-93, 98 

 skin reactions to, 456, 461, 462, 466 

 source of A substance, 265 

 toxic action, 94, 97, 98 

 virulence enhanced by, 202-203 

 See also Autolysis of Pneumococcus 



Autolyse transmissible, 61 



Autolysis of Pneumococcus, 52-55 

 and bile solubility, 60-62 

 effect of hydrogen peroxide, 78 

 enzymes, 54 



hydrogen ion concentration and, 53 

 in relation to hemolysis, 86 

 prevention by serum, 53 

 temperature, 53 



Automatic transfer device 



in cultivation of Pneumococcus, 41 

 increase in virulence of cultures, 

 204 



Auto-oxidation, effect on hemotoxin, 

 84 



Avery's method of type determina- 

 tion, 123 



Avian serum, 545 

 chill-production, 562 

 protective antibodies in, 410 



Bacillus acidophilus, peroxide forma- 

 tion by, 75 

 Bacillus aerogenes, polysaccharide in, 



262 

 Bacillus bulgaricus, peroxide forma- 

 tion by, 75 

 Bacillus coli 



polysaccharide in, 262 

 relation to Pneumococcus, 261 

 Bacillus friedlanderi, 12, 13, 18, 20 

 and Pneumococcus, differentiation, 



17 

 capsular polysaccharides, 246, 260, 



262 

 classification, 260 

 in lobar pneumonia, 217 



