776 



INDEX 



Bottling antipneumococcic serum, 596 



British Statutory Rules and Orders, 

 592 



British Therapeutic Substances Act, 

 592 



Bronchopneumonia, pneumococcal 



types, 219-221 



Broth. See Media 



Bulk sterility and potency tests in 

 antipneumococcic serum produc- 

 tion, 590 



C Fraction of Pneumococcus 



compared to non-specific IV carbo- 

 hydrate, 258 



in non-type-specific R strain, 258 



isolation, 256-258, 295, 636-637 



precipitin reaction, 368-370, 441 



precipitins in lobar pneumonia, 441 



properties, 257 



relation to non-protein fraction of 

 Gonococcus, 248 



relation to purpura, 257 



skin reactions to, 464, 465, 471, 472 



Type IV, 257 



type-specificity, 257 

 Capsular polysaccharide (s) of Pneu- 

 mococcus 



acetyl group in, 277-288 



administration by mouth, 349 



aldobionic acid in, 245, 246 



anaphylaxis, 255, 448-449, 450, 454 



antagonistic action, 351-353 



antigenicity, 251, 252 



as antiopsonins, 399, 400 



as precipitinogen in urine, 123-124, 

 363-365, 366, 370, 373 



B. friedlanderi compared with, 246, 

 260, 262 



blood-group specific A substance, 

 287-288 



carbohydrates from other sources, 

 258-263 



effect of alkali and of acid upon, 

 295 



excretion, 350 



first description, 243-252 



galacturonic acid in, 246 



Capsular polysaccharide (s) of Pneu- 

 mococcus (cont.) : 



glucose, 246 



immunological behavior, 255 



in agglutination, 364 



injection, intradermal, 344-346 



methods of preparation, 244, 288- 

 296, 623-625, 634 



microdetermination, 374 



ophthalmic reaction, 457-458 



optical rotation, 246, 254, 255, 257, 

 274, 281, 291, 292, 293 



physicochemical properties, 296-297 



properties, 246, 247 



protective antibodies induced by, 

 411 



relation to gonococcal polysaccha- 

 ride, 248 



skin reaction, 460, 463, 464, 466, 473 



soluble specific substance, 243, 266, 

 269 



thermostability, 294 



Type I, 245 



Type II, 244, 245 



Type III, 244, 245 



Type IV, 257-259 



Type VIII, 274, 275 



uronic acid in, 346 



viscosity of, 297 



See also Enzymes, polysaccharide- 

 splitting 

 Capsule of Pneumococcus, 3, 6, 7, 11, 

 14, 31, 32-35 



mucin in, 3, 7, 33, 239 



stains, 33-35 



substances favoring development, 35 



variation during propagation, 7 

 Carbohydrate fermentation by Pneu- 

 mococcus, 67-70 



acetic acid, formation, 71 



alcohols, 70 



amylase, 67 



arabinose, 70 



dextran, 70 



dulcitol, 70 



erythritol, 70 



exhaustion of carbohydrate, 70 



formic acid, formation, 71 



