782 



INDEX 



Growth of Pneumococcus (cont.) : 



in immune serum, 362, 420 



in milk, 45 



inhibition, 40, 42, 394, 396, 399, 429 



inoculum, 41 



media. See Media; Media, differ- 

 ential 



on agar, 46 



on blood agar, 46 



on gelatin, 41, 42 



on Loeffler's serum, 46 



on potato, 46 



peroxide formation during, 44 

 Guinea pig(s) 



purpura in, 88 



susceptibility to Pneumococcus 

 as carrier, 186 

 avitaminosis and cold, effect of, 



187 

 epidemics in, 186 

 inhalation, 185 

 inoculation, 185, 187 

 pigmentation, 187 

 pregnancy, effect of, 187 

 spontaneous infection, 186 

 Gum arabic, polysaccharide in, 261 



Health Organisation of the League of 

 Nations, potency tests, 569, 650- 

 651 

 Hemolysin, pneumococcal 



lability, 82 



thermolability, 84 



See also Hemolysis, pneumococcal; 

 Hemotoxin 

 Hemolysis, pneumococcal 



effect of cholesterol, 83 



effect of egg albumen, 84 



effect of normal serum, 84 



effect of peptone, 84 



in cultures, 83, 84 



in plate cultures, 46 



of erythrocytes, 82, 85 



pseudo-hemolysis, 83 



relation to autolysis, 86 



relation to purpura production, 89 



See also Hemolysin, pneumococcal 

 Hemophilus influenzae carbohydrate, 

 303 



Hemotoxin (s), 82-86 

 antigenicity, 85, 340 

 effect of auto-oxidation, 84 

 of tetanus bacilli, 86 

 of Welch bacillus, 86 

 quantitative measurement, 85 

 relation to necrotizing principle of 



pneumococcal extracts, 92 

 See also Hemolysis, pneumococcal 

 Heterophile antibodies, 387-388 

 Horse (s) 



age as factor in selection of, 523 

 immune serum from, 27, 522, 593- 



594, 600 

 immunization, 522-543 

 paradoxical reaction to injections 



of vaccine, 196, 528-540 

 selection of, 522-523 

 susceptibility to Pneumococcus, 

 195-196 

 Host response 



influence of virulence, 326-327 



of mice in protection tests, 420, 572, 



574 

 of rabbits to intradermal infection, 



185 

 to antigenic action of Pneumococ- 

 cus, 351 

 unsolved problems, 618-619 

 See also Pathogenicity of Pneumo- 

 coccus; and under particular ani- 

 mal 

 Hydrogen ion concentration 

 acid death-point of Pneumococcus, 71 

 effect on autolysis, 53, 54 

 effect on enzymes, 66, 67 

 effect on growth of Pneumococcus, 



39 

 in acid production by Pneumococ- 

 cus, 70-71 

 in dissolution of Pneumococcus, 62 

 in media, 623, 625, 634 

 in pneumonic exudates, 442 

 in therapeutic antipneumococcic se- 

 rum, 557 

 Hydrogen peroxide. See Peroxide for- 

 mation 

 Hygienic Laboratory, United States, 

 potency tests, 648-650 



