786 



INDEX 



Monkey(s) (cont.): 



experiments on, 481-483 



in tests for chill-producing proper- 

 ties of serum, 564-565 



susceptibility to Pneumococcus 

 as carrier, 192 

 Cebus capucinus, 192, 193 

 Ceropithecus callitrichus , 192 

 epidemics in, 191, 483-484 

 inoculation, 191-193, 577 

 lobar pneumonia in, 192, 193 

 Macacus cynomolgos, 193, 368 

 Macacus rhesus, 192, 193 

 Pithecus philippinensis, 192 

 variations, individual, 193 

 Morphology of Pneumococcus, 30-35 

 Mouse (mice) 



immunizing action of polysaccha- 

 rides, 255 



in isolation of Pneumococcus, 35, 

 626-630 



in potency tests on antipneumococ- 

 cic serum, 407-408, 567-576, 653- 

 661 



in protection tests, host response, 

 420, 572, 574 



in safety tests for antipneumococcic 

 serum, 588-589, 591 



in serological classification, 104, 

 105, 106, 108, 111, 113, 114 



in tests for preservatives, 588 



in therapeutic tests on antipneumo- 

 coccic serum, 578-579 



in type determination, 120-122, 628- 

 630, 631 



protective action of enzyme in, 305- 

 306 



purpura in, 87, 89, 90 



susceptibility to Pneumococcus 

 age, 189 

 as carrier, 189 

 Bacillus typhi murium, 190 

 body-weight, 189, 190 

 breed, 189 

 dose of Pneumococcus necessary 



to infect, 188 

 effect of alcohol, 190 

 effect of toxins, 97, 99 



Mouse (mice) (cont.): 

 susceptibility to Pneumococcus 

 (cont.): 



inoculation, 188-190 

 mixed infection, 188 

 monocytes, 190 

 pigmentation, 187, 188 

 variation in response to infection, 



187, 190, 420, 572, 574 

 white cells, 190 

 Mucin 



in blood, 240 

 in capsule, 3, 7, 33, 239 

 Mucin, gastric, virulence of Pneumo- 

 coccus enhanced by, 202 

 Mutation 

 in serological type, 156-169 

 in species, 169-177 

 Mycobacteriaceae, 320 



National Institute of Health, potency 



tests, 567, 592, 648-650 

 Natural immunity. See Immunity to 



Pneumococcus 

 Necrotin, 92 



Necrotizing principle of Pneumococcus 

 in autolysates, 92-93, 98-99 

 relation to hemotoxin, 92 

 Nephritis, Pneumococcus in, 16, 17 

 Neufeld Quellung phenomenon. See 



Quellung phenomenon 

 Nitrogen determination, precipitation 



tests, 643-644 

 Normal individuals 

 opsonins in, 395-397 

 Pneumococcus in, 215-216 

 See also Carriers of Pneumococcus 

 Nucleoprotein(s) of Pneumococcus. 



See Protein fraction (s) 

 Nutrient media. See Media 



Oliver's method of type determina- 

 tion, 126 

 Olmstead's serological groups, 108- 



109 

 Ophthalmic reactions 



capsular polysaccharides in, 457-458 

 in rabbit, 457 



