792 



INDEX 



Protective antibodies to Pneumococ- 



cus (cont.): 

 induced by synthetic antigens, 411 

 isoelectric zone, 412, 416, 417, 550, 



551, 552, 555 

 isolation 



by alcohol, 553-554 



by ammonium sulfate, 413, 548- 

 549 



by carbon dioxide, 553 



by dialysis, 412, 550 



by dilution with water, 412, 550- 

 553 



by dissociation of specific precipi- 

 tates, 414, 418-419, 554-555 



by sodium chloride, 553 



by sodium sulfate, 549-550 

 molecular-size, 416-418 

 natural, 436 

 normal serum, 434 

 origin, 407 



quantitative estimation, 419-420 

 relation to other antibodies, 377- 



379, 409-410, 584-587 

 specificity, 408-409 

 ultracentrifugation, 414-417, 555 

 ultrafiltration, 417-418, 555 

 Protein fraction (s) of Pneumococcus 

 antigenicity, 242, 247, 250, 253, 345, 



444, 526 

 antiprotein precipitins, 367-368 

 in anaphylaxis, 451 

 in ophthalmic reactions, 457 

 in skin reactions, 456, 464, 471-472 

 isolation, 242, 636 

 relation to protein from Gonococ- 



cus, 248, 370 

 See also Conjugated carbohydrate- 

 proteins 

 Protein poisons, relation to pneumo- 

 coccal toxins, 100-101 

 Proteolysis of Pneumococcus, 65-66 

 and toxins, 94, 95 

 peptonase, 66 

 protease, 66 

 Proteolytic enzymes in Pneumococcus. 



See Enzymes, pneumococcal 



Protocols and records, potency tests, 



659-661 

 Pseudo-hemolysis, 83 

 Puerperal sepsis, Pneumococcus in, 226 

 Purpura 



and virulence, 88 



in guinea pigs, 88 



in man, 86, 87 



in mice, 87, 89, 90 



in pneumococcal infections, 86, 87 



in rabbits, 88 



produced by cellular carbohydrates, 

 90, 91, 274 



relation to C Fraction, 257 

 Purpura-producing principle 



antigenicity, 89 



characters, 88 



effect of bile salts, 90 



effect of polysaccharide-splitting 

 enzymes on, 321 



effect of sodium choleate, 90 



effect of sodium desoxycholate, 90 



effect on blood platelets, 88 



effect on red blood cells, 88 



relation to cellular carbohydrate, 

 90, 91 



relation to hemolysin, 89 

 Pyosalpinx, Pneumococcus in, 226 



Quellung phenomenon, 33 

 as potency test on antipneumococ- 



cic serum, 581 

 in type determination, 128, 131-132, 



630, 632-633 

 use of immune horse or immune 



rabbit serum in, 594 



R forms. See Rough (R) forms 

 Rabbit (s) 



immune serum 



antibodies in, nature of, 381-382, 



418-486 

 in complement fixation, 380-382 

 in protection tests, 121, 148 

 in treatment of pneumonia, 600 

 in type determination, 121 

 production of, for diagnosis, 594- 

 595 



