INDEX 



795 



Skin reactions (cont.): 



to C Fraction, 464, 465, 471, 472 

 to capsular polysaccharides, 460, 



463, 464, 465, 466, 473 

 to carbohydrates, cellular, 465, 466 

 to nitrates, 97, 440, 462 

 to heat-killed Pneumococcus, 456, 



457 

 to nucleoproteins, 456 

 to proteins, 464, 471-472 

 to saline suspensions, 461, 463 

 to somatic proteins, 464, 471 

 to toxins, 97, 99, 461, 468, 471 

 unsolved problems, 619-620 

 Slide agglutination in type determi- 

 nation, 127-131 

 Smooth (S) forms of Pneumococcus 

 antigenicity, 344 



colony appearance, 137-139, 147-149 

 differential medium, 152 

 in composite cultures, 141-142 

 in vivo variation, 145-147 

 respiratory capacity, 150-152 

 reversion of R forms to, 147, 154- 



155, 157 

 type transformation, 156-160 

 Smooth variants (V and N), 153 

 Soaps. See Chemotherapy; Bile solu- 

 bility 

 Sodium choleate and purpura-produc- 



ing principle, 90 

 Sodium desoxycholate and purpura- 



producing principle, 90 

 Sodium formaldehyde sulfoxylate in 

 treatment of pneumococcal infec- 

 tion, 511 

 Sodium hydroxide in lysis of Pneu- 

 mococcus, 59 

 Sodium linoleate in lysis of Pneumo- 

 coccus, 59, 60 

 Sodium oleate 



adjuvant action of, on immune se- 

 rum, 509 

 in lysis of Pneumococcus, 59 

 Sodium ricinoleate 



in preparation of toxins, 96 

 pneumococcidal action, 63, 509 



Soluble specific substance (SSS) 

 as antigen. See Capsular polysac- 

 charide (s) 

 media for preparation, 243, 623- 



625, 634 

 precipitation in urine, 123-124, 240, 

 633-635 

 Somatic carbohydrate (s). See C Frac- 

 tion 

 Somatic protein (s). See Protein frac- 

 tion (s) 

 Spleen 



as inoculum, 18, 20 

 for preservation of Pneumococcus, 

 52 

 Sputum, 2, 8, 9, 25 

 as antigen, 21 



as medium for cultivation of Pneu- 

 mococcus, 37 

 immune substances in, 442 

 in methods of type determination 

 bile solution, 126-127 

 digestion, 124-125 

 Pneumococcus in, 2, 8, 9, 25 

 precipitinogen in, 124 

 SSS. See Soluble specific substance 

 Stain (s), capsule, 6, 33-35 

 Buerger, 34 

 Friedlander, 33 



Gram, Burke's modification, 31, 84 

 Gram, Sterling's modification, 31, 34 

 Gram-Weigert, of tissues, 32, 34 

 Hiss, 34 

 Huntoon, 34 

 Leifson, 34 



L^vy-Bruhl and Borin, 34 

 MacConkey, 33 

 Malone, 34 



Wadsworth, of tissues, 35 

 Welch, 34 

 Wherry, 34 

 Staining methods, 31-35 

 capsule. See Stain (s), capsule 

 stain, differential, 31-32 

 Standardization of antigens, 331, 532- 



533 

 Staphylococcus aureus, peroxide for- 

 mation by, 76 



