798 



INDEX 



Urine (cont.) : 



precipitation test, as method of 

 type determination, 123-124, 633- 

 635 



precipitinogen in, 123-124, 366, 370, 

 373, 633-635 



soluble specific substance in, 123- 

 124, 240, 633-635 

 Uronic acid in acetylated polysac- 

 charide, 280 



Vaccinal immunity 

 after ingestion, 493 

 after intradermal injection, 491, 492 

 after lipovaccine, 492 

 after subcutaneous injection, 492, 



493 

 appearance and duration, 490-493, 



502 

 duration, 488 



water soluble fraction, 501, 502 

 Vaccine therapy of pneumonia, 503- 



506 

 autolysates, 504 

 killed pneumococci, 504 

 mixed vaccines, 505 

 rationale, 503 

 Vaccines, pneumococcal, 479-506 

 acid-soluble portion of pneumococ- 

 cal cell, 485 

 antibodies evoked, 485 

 as agent in reversion, 155-156 

 autogenous vaccines, 499, 500 

 autolysates, 481, 483, 488 

 cultures 



heat-killed, 483 



killed by Merthiolate, 487 



soaped, 487 



washings of agar, 487 

 dosage, 483, 484, 494, 496, 497, 498, 



501 

 egg-white as adjuvant, 487 

 experiments on monkeys, 481-483 

 extracts 



neutralized alkaline, 483 



of Pneumococcus, 481, 483 

 nitrates, 483 

 formalinized suspensions, 483 



Vaccines, pneumococcal (cont.): 

 heat-killed cultures, 483 

 Immunogen, 483 

 in prophylaxis, 494-503 

 ingestion, 487, 488, 489, 493 

 injection, route and spacing, 486^89 

 intact cell, 487 

 limitations, 502 



lipovaccine, 483, 492, 495, 497, 498 

 mixed, 496, 497, 499, 500, 501 

 Pneumocholin, 334, 483 

 results in man, 493-506 

 saline suspension, 496 

 devitalized, 480-481 

 soluble specific substance, 484 

 solutions of Pneumococcus, 481 

 special constituents of Pneumococ 



cus, 484-485 

 therapy. See Vaccine therapy 

 transformation by, 158-160 

 types of, 483 



See also Vaccinal immunity 

 Variants of Pneumococcus 

 action on inulin, 69 

 agglutinability, 140, 362-363 

 bile solubility, 140-141, 149 

 effect of anti-R serum, 154 

 electrophoretic potential, 144 

 fermentation of glucose, 67-68 

 Fldtterformen, 152 

 forms a, b, c, d, and e, 152 

 intermediates, 144 

 methemoglobin formation, 148 

 modifications A, B, and C. See Dis- 

 sociation 

 mucoid, 161, 163, 164, 166, 167 

 P-C, 153 



respiratory capacity, 150-152 

 reversion by anti-R serum, 154 

 reversion by mouse passage, 154 

 reversion by pneumococcal vaccine, 



155-156 

 Smooth (V and N), 153 

 type-specificity, 143 

 virulence of, 82, 140-141, 212 

 Variation. See Dissociation of Pneu- 

 mococcus; Transformation of 

 Pneumococcus 



