CONTENTS 



Dedication v 



Preface vii 



Introduction xv 



Conventions xix 



Symbols xix 



CHAPTER 1 



lodoacetate and lodoacetamide 1 



Historical Development 1 



Chemical Properties 7 



Inhibition of Enzymes 18 



Effect on Electron Transport Systems 52 



Effects on Oxidative Phosphorylation 60 



Anaerobic Glycolysis and Fermentations 61 



Tricarboxylate Cycle 87 



Phosphorus Metabolism 98 



Aerobic Metabolism of Carbohydrate 101 



Effects on Lipid Metabolism 140 



Effects on Protein and Amino Acid Metabolism 146 



Effects on Porphyrin Synthesis 155 



Effects on Photosynthesis 156 



Specificity of Inhibition of 3-PGDH and EM Pathway 167 



Penetration into Cells and the Effects of pH 168 



Effects on Permeability and Active Transport 171 



Effects on Skeletal Muscle 195 



Effects on the Heart 211 



Effects on Smooth Muscles 224 



Theories of the Mechanism of Muscle Rigor 227 



Effects on Nerve Function 228 



Effects on the Retina and the Eye 232 



Effects on Miscellaneous Cell and Tissue Functions 240 



Effects Observed in the Whole Animal 244 



Effects on Mitosis, Growth, and Differentiation 253 



Effects on Neoplastic Growth 260 



Effects on the Growth of Microorganisms 266 



Comparison of Halogenated Acids and Their Derivatives 270 



