CONTENTS XUl 



Effects on Tissue Functions 498 



Effects in the Whole Animal 506 



Antimitotic Actions 520 



Effects on Neoplastic Cells 538 



Antibacterial Activity 543 



Effects on Fungi and Yeasts 560 



Effects on Algae and Protozoa 573 



Effects on Invertebrates 575 



Effects on Virus and Phage 578 



Distribution and Metabolism 580 



Naturally Occurring Quinones 584 



Aminophenols and Phenylenediamines 585 



CHAPTER 6 



Arsenicals 595 



Chemical Properties 599 



Reactions of the Arsenicals 608 



Inhibition of Enzymes 615 



Electron Transport and Oxidative Phosphorylation 657 



Tricarboxylate Cycle 662 



Accumulation of Keto Acids and Other Substances 668 



Glucose Metabolism 674 



Respiration 677 



Various Metabolic Pathways 689 



Penetration of Arsenicals into Cells 698 



Active Transport 701 



Tissue Functions 706 



Effects Observed in the Whole Animal 712 



Effects on Protozoa 733 



Effects on Bacteria, Fungi, Yeasts, and Viruses ......... 754 



Resistance to the Arsenicals 757 



Effects on Growth and Mitosis 769 



Carcinostatic and Carcinogenic Actions 772 



Effects of pH on Arsenical Inhibition 775 



Tissue Distribution 778 



Metabolism of the Arsenicals 785 



Thioarsenites 788 



Arsine 790 



CHAPTER 7 



Comparison of SH Reagents 795 



References 821 



Author Index 897 



Subject Index 947 



