954 



SUBJECT INDEX 



ionization constant, 605 

 lethal dose, 722, 748 

 resistance factor in trypanosomes, 758 

 structure of, 601 

 trypanocidal dose, 748 

 Arsacetin oxide, 

 lethal doses, 722 

 trypanocidal dose, 748 

 Arsanilic acid (atoxylic acid), ionization 



constant, 605 

 Arsenate, 



compared with arsenite, 596 

 fumarase, 650 

 reduction in tissues, 786 

 Arsenicals, see also Arsenite, Phenylarse- 

 noxides, and other specific arsenicals, 

 acetate metabolism, 663, 665 

 active transports, 701-706 

 amino acid accumulation, 672 

 bacterial growth, 754-755 

 binding to blood proteins, 783 

 blood urea, 692-693 

 bond characteristics, 606 

 capillaries, 713, 726-729 

 carcinostasis, 772-775 

 central nervous system, 597, 706-707 

 chemical properties, 599-607 

 cholinesterases, 653-654 

 determination of, 607 

 disubstituted, reactions with thiols, 

 612-613 



electron transport, 657-662 

 enzyme inhibitions, 615-656 



comparison of arsenicals, 654-655 



comparison with other SH reagents, 



818 



detection of mono- and dithiol 



groups, 617-621 



mechanisms involved, 616-617 



pH effects, 649-650 



potentiation by thiols, 645-647 



rates of inhibition, 649 



specificity, 655-656 



types of inhibition, 647-649 

 enzyme stimulation, 621, 645 

 fatty acid oxidation, 690 

 fecal excretion of, 782 

 fungal growth, 755-756 



glucose metabolism, 674-677 



growth, 725-726, 769-772 



heart, 710-712 



hydration of, 604 



intestine, 709 



keto acid accumulation, 668-674 



a-ketoacid oxidase, 651-653 



lethal doses, 717-722, 747-748 



lipid metabolism, 689-693 



metabolism of, 785-788 



methylation by fungi, 787-788 



mitosis, 769-772 



monosubstituted, reactions with thiols. 



612-613 



muscle, 597, 708-709 



nomenclature of, 600 



oxidative phosphorylation, 657-662 

 potentiation by thiols, 659-662 



paramecia, 749-751 



penetration into central nervous sys- 

 tem, 783-784, 780 



permeability to, 698-700 

 relation to toxicity, 723-725 



phage proliferation, 756 



phospholipid metabolism, 692 



porphyrin biosynthesis, 695-696 



protein biosynthesis, 693-695 



protozoa, 733-754 



protozoa infections, 733-734 



reactions with proteins, 613-615 



reactions with thiols, 608-613 



resistance to, 757-768 



characteristics of resistant strains, 



762-764 



conditions for development, 758 



cross resistance, 760-762 



degrees of, 758-759 



higher animals, 764-765 



mechanisms involved, 765-768 



occurrence of, 757-758 



rate of development, 758-759 



role of permeability, 766-768 



respiration, 677-689 



factors in inhibition, 684-686 

 in vivo inhibitions, 686-688 

 mechanisms involved, 688-689 

 resistant fraction, 682-683 



tissue distributions, 778-785 



