1024 



SUBJECT INDEX 



Trypanosoma gambiense, resistance factor 



to tryparsamide, 759 

 Trypanosoma hippicum, respiration (glu- 

 cose), 



oxophenarsine, 679, 686 

 Trypanosoma leivisi, 



motility of, iodoacetate, 270 

 respiration, iodoacetate, 270 

 Trypayiosoma rhodesiense, 

 iodoacetate killing of, 270 

 resistance to arsenicals, 759 

 respiration, 



iodoacetate, 122 



tryparsamide oxide, 679 

 Trypanosoma vivax, 



motility of, iodoacetate, 270 

 respiration (glucose), arsenite, 680 

 Trypanosomes, see also Trypanosoma spe- 

 cies, 



arsenical binding in, 723, 734, 736-737 

 arsenical uptake, 700 

 glucose metabolism, oxophenarsine, 

 673 



metabolic characteristics of, 752 

 motility of, 



arsenicals, 735 



iodoacetate, 270 

 phenylarsenoxides, pH effects, 775-778 

 resistance to arsenicals, 757-768 



metabolic characteristics of strains, 



763-764 



permeability changes, 766-768 



respiratory inhibition, 763 



SH contents, 762-763 

 respiration, 



arsenicals, 752 



iodoacetate, 270 

 Trypanosomiasis, 



arsenicals, 596, 733, 738 

 iodoacetate, 270 



1 ,2-naphthoquinone-4-sulfonate, 574- 

 575 

 Tryparsamide, 



enzyme inhibitions, 622, 632, 637, 644 

 ionization constant, 605 

 kidney damage, 705 

 lethal doses, 721 

 liver damage, 716 



optic nerve damage, 716 



penetration into central nervous sys- 

 tem, 784 



reduction in tissues, 715-716, 778, 



786 



resistance factor in trypanosomes, 758- 



759 



structure of, 601 



trypanocidal kinetics, 738 



trypanosomiasis, 596 

 Tryparsamide oxide (reduced tryparsa- 

 mide), 



binding in trypanosomes, 736 



lethal doses, 721 



resistance factor in trypanosomes, 759 



respiration of trypanosomes, 679 



trypanocidal action, 735, 737-738 

 Trypsin, 



arsenicals, 615, 643 



maleic hydrazide, 331 

 Tryptophanase, 



chloroacetophenone, 283 



iodoacetate, 153 

 Tryptophan:o; - ketoglutarate transami- 

 nase, see Transaminases 

 Tryptophan pyrrolase, 



p-benzoquinone, 445, 461-462 



hydroquinone, 445, 461-462 



liver levels in vivo, alloxan, 405 

 Tryptophan synthetase, 



hydroquinone, 461 



SH reagent comparison, 815 

 Tubifex tuhifex eggs, 



cleavage, quinones, 520-526 



posterior regeneration, iodoacetate, 260 



uptake of ?)-benzoquinone, 523-524 

 Tumor 256, growth in vivo, 



iodoacetate, 264 

 Tumor C-63, growth in vivo, 



iodoacetate, 265 

 Tumor C-180, growth in vivo, 



iodoacetate, 265 

 Tumors, see also specific tumors, 



cholesterol biosynthesis, iodoacetate, 



262 



fatty acid biosynthesis, iodoacetate, 



145 



glucose utilization, iodoacetate, 261 



