ENDOMYCETALES 149 



Megalocitosporides Wernicke, Centralbl. Bakt. 12: 859-861, PI. 6, 1892; 

 Posadas, Tesis, Buenos Aires, 1894. 



Coccidium neoplasicum Canton, Trataclo de los zooparasitos del cuerpo 

 umano, Buenos Aires, 108-122, 1897. 



Posadasia esferiformis Canton in Posadas, Psorospermiosis infectante gen- 

 eralizada, Buenos Aires, 1898. 



Oidium coccidioides Ophiils, Jour. Exp. Med. 6: 443-485, Pis. 34-38, 1905. 



fOidium protozooides OpMls, Jour. Exp. Med. 6: 443-485, Pis. 34-38, 1905. 



Zymonema immitis Froilano de Mello & Pernandes, Arq. Hig. Pat. Exot. 

 6: 278-279, 283-284, 1918. 



Mycoderma immite Verdun & Mandoul, Precis Parasitol. 769-771, 1924. 



Pseudococcidioidcs Mazzai Fonseca in Mazza & Parodi, Bol. Inst. Clin. 

 Quirurg. Univ. Buenos Aires 4: 495-502, Figs. 13-19, 1928. 



Coccidioides esferiformis Moore, Ann. Missouri Bot. Card. 19: 397-428, 1932. 



Not Blast omycoides immitis Castellani, Amer. Jour. Trop. Med. 8: 381, 

 1928, etc., wliicli is Geotrichum immite Agostini (p. 219). 



Eight types of lesions have been reported ; primary cutaneous or primary 

 pulmonary lesions both with later generalization, primary pulmonary lesions 

 with secondary subcutaneous lesions, primary pelvic involvement, and pri- 

 mary meningeal or spinal cord involvement without any skin lesions ; primary 

 joint lesions and primary subcutaneous lesions. It is supposed that the organ- 

 ism enters through the lungs or through skin injuries. The lesions clinically 

 resemble tuberculous or sporotrichotic lesions. Most of the cases seem to have 

 come from the San Joaquin Valley or the southern countries of California. 

 Mortality is at present high, being about 65% of the cases according to a 

 recent estimate. 



Hyphae 2-4/a in diameter, giving rise to raquet mycelium and chlamydo- 

 spores 5 x 11/^. Cells may give rise to arthrospores. Asci 4-80/a in diameter 

 (Fig. 24, 19), filled with numerous ellipsoid ascospores, up to 2.5/a in diameter 

 (Fig. 24, i). 



On malt extract agar (pH 5.2) colony creamy white, becoming brown 

 after several weeks, loose, cottony, forming concentric circles, chlamydospores 

 abundant, 4-7/a (Fig. 24, 16, 17). On Sabouraud agar (pH 5.6) growth rapid, 

 cream color when young, light brown in age, mycelium cottony, hyphae 2.5/x 

 in diameter (Fig. 24, 6, 8). On glycerol agar (beef extract agar with 6% 

 glycerol) growth abundant, thick at the inoculum, then thinner, surrounded 

 by an elevated plateau, hyphae 2.5-3//i in diameter, hypnospores 7/* in diameter 

 (Fig. 24, 7, 10). On gelatin, growth conic with loose, cottony, branching, 

 septate mycelium, 2/t in diameter. On Raulin's solution, colonj^ white, fila- 

 mentous, growing in large flakes, partly submerged in the medium, hyphae 

 only Ifx in diameter, long with few septa, swollen portions 2 x 6/a, with some 

 chlamydospores and arthrospores. In Richard's solution, growth similar to 

 that on Raulin's but more abundant, hyphae more slender. Gelatin liquefied. 



