ENDOMYCETALES 



153 



the ascus as reported for Paracoccidioides nor are eonidia reported in the 

 literature for the latter genus. 



So far only two species have been reported, from both the United States 

 and Central America. They produce fatal infections characterized by emacia- 

 tion, severe anemia with a marked leucopenia, splenomegaly, enlargement of 

 the liver, and irregular pyrexia. The affected organs become necrosed, and 



Fig. 26. — Histoplasma capsulatum. 1, S, 4, 9, IS, li, mycelium on various media, some 

 showing' asci, eonidia, and clavate terminal cells ; 2, large cells from submersed mycelium ; 5, 

 young ascus (?); 6, 7, 10-12, 15-17, spherical tuberculate cells, probably degenerate asci. on 

 various media ; 8, large spherical cell showing vacuoles ; 18, ascus showing oil globules ; 19, 

 ascus showing protoplasmic network and vacuoles; 20, germinating ascus (?). 



the liver develops cirrhosis. The lungs and both small and large intestines 

 are studded with pseudotubercles, giving the appearance of miliary tubercu- 

 losis. The peribronchial lymph nodes are enlarged and show ulcerated tubercles. 

 Histoplasma capsulatum Darling, Jour. Amer. Med. Assn. 46: 1283-1285, 

 1906; Arch. Int. Med. 11: 107-123, 1908; Jour. Exp. Med. 11: 515-531, 1909. 



