240 MEDICAL MYCOLOGY 



chains of 3-4 cells when the sprouting is bipolar, or in groups when sprout- 

 ing is multipolar. These cells have a thin wall, more or less granular content, 

 and a rather large vacuole which is almost always central. After a while 

 hyphal forms appear, composed of mother cells and blastospores, rich in proto- 

 plasm and of very variable size. Others are made up of several long cells. 

 Blastospores lateral, spherical, or ovoid in form. Growth good both at room 

 temperature and at 37° C. Mostly gram-positive, though in part negative. 

 With Gueguen stain colored an intense blue. 



On solid media, colonies at first hemispheric, creamy, humid, not adherent 

 to medium. With age the center flattens while the edge curves gradually 

 downward to the medium. Good growth on Sabouraud glucose agar, potato 

 or carrot and glycerol, or gelatin. Scant growth on agar in 4 days. In simple 

 broth or Sabouraud glucose broth, good growth in 48 hours with the forma- 

 tion of a pulverulent sediment on the sides of the tube. Starch paste not lique- 

 fied. Probably no fermentation of sugars, although the author reports slight 

 fermentation of arabinose and maltose, more of inulin. Milk coagulated in 

 48 hours with acid formation and partial digestion of clot. Coagulated human 

 serum digested. Gelatin not liquefied. 



Parendomyces zeylanoides (Castellani, Douglas & Thompson) Dodge, 

 n. comb. 



Monilia zeylanoides Castellani, Douglas & Thompson, Jour. Trop. Med. Hyg. 

 28: 257-258, 1925. 



Isolated from a case of bronchial infection, but case history not given. 



Colonies white, lead agar not darkened. No fermentation. Litmus milk 

 clotted. No liquefaction of gelatin. 



Parendomyces albus Queyrat & Laroche, Bull. IMed. Soc. Med. Hop. Paris 

 III, 28: 111-136, 1909. 



Cryptococcus alhiis Castellani & Chalmers, Man. Trop. Med. ed. 3, 1080, 

 1919. 



Monilia alba Sartorv\ Champ. Paras. Homme Anim. 707, 1923, not Castel- 

 lani, 1911. 



Candida alba Almeida, Annaes Fac. Med. Sclo Paulo 9: 11, 1933. 



Isolated from little white spots on surface of the vagina. Spots easily 

 washed off but recurrent within 12 hours. Patient experienced burning sen- 

 sation and was unable to sit or sleep. Irrigation with a variety of antiseptics 

 twice a day gave relief, but no cure. Finally arrested by a dressing of creo- 

 sote and olive oil (20 gm. to 60 gm.). Rabbits, rats, mice, and guinea pigs 

 found susceptible. Pigeons, monkeys, and kittens not susceptible. 



In the yeastlike form, cells are ovoid, slightly j^ointed at each extremity, 

 sometimes pyriform, more rounded in age. Length 3.4/a, width 2.3/*, with 

 extreme variations 6-2.5 x 4.5-1/x. Easily stained Avith aniline dyes. Gram- 

 positive. Filamentous forms appear only in liquid media and are rarely 8-10 

 cells long. Reproduction is by budding and chlamydospores which are from 



