640 



MEDICAL MYCOLOGY 



Grown on neutral Raulin's (Diercks) medium, beef broth gelatin, malt, 

 agar, bread, potato, and Sabonraud agar (prepared according to the direc- 

 tions of Biourge). Stab colony white with sulphur colored center, then green 

 (glaucus of Saccardo Chromotaxia) finally dark green (atrovirens), reverse 

 sulphur. Streak practically same color, changes finally, folded and fuliginous 

 (11 Saccardo Chromotaxia), reverse luteous, the orange finally badious in 

 the central zone with clear orange (137, Code des Couleurs). In beef gelatin, 

 the reverse finally becomes ferruginous. In Sabouraud's conservation agar, 

 colonies remain pinkish white (53a, Code des Couleurs). 



This organism belongs in the Aspergilloid section, close to P. platense 

 Spegazzini. 



Penicillimn mycetomag'enum Mantelli & Negri, Giorn. R. Accad. Med. 

 Torino 78: 165, 166, 1915 [as P. mycetogenum] ; Negri Atti R. Accad. Sci. 

 Torino 66: 67-78, 1921. 



Fig. 102. — Penicillium Bertai. (After Talice & Mackinnon 1929.) 



Isolated from the foot of a man of thirty in Turin, Italy. The foot had 

 been stepped on by an ox and gradually developed lesions which did not 

 respond to iodine or KI treatment and finally, after 3 years, had to be ampu- 

 tated. In section, the foot showed a fibrous periphery and a soft interior filled 

 with black grains. Organism pathogenic to pigeon but not to guinea pig. 



In grains, hyphae septate, crowded into pseudosclerotia, subspheric or 

 lobate, carbonaceous, 200-500ju, in diameter, solitary or in groups of two or 

 three. Outer hyphae of the granules larger, 2.2/x in diameter, shorter, twisted 

 and with a clavate apex, bound together into a crust by a black cement. 

 Central hyphae are hyaline, 1.5/i in diameter, with conidial cells larger, some 

 terminal, ovoid or pyrif orm, 3-4/a in diameter, with some larger intercalary ones 

 6-10.5/t (Carter's capsules). In cultures chlamydospores 4-5/a in diameter, 

 yellowish gray, blackening the substrate, reproducing abundantly at 20°-25° 

 C, but growing slowly and normally between 3° and 37° C, hyaline, septate. 

 Conidiophores not in coremium, septate, 2-3 furcate with the next rank verti- 



