830 MEDICAL MYCOLOGY 



Hyphae repent, 2-3. 3/a in diameter, in old cultures up to 6/a, with large oil 

 droplets, sparingly septate ; conidiophores erect, not septate, SOAO/x tall, 2/* thick 

 at the base, tapering upward ; conidia in heads, lO-lS/x in diameter ; conidia ovoid 

 to ellipsoid, 3-6 x 1.7-2.3/^, mostly 3.3 x 2/x. 



Colonies on malt agar with radial furrows, cottony, grayish in the center 

 with some small coremia, finally bright reddish brown, reverse reddish yellow 

 {Code des Couleurs 178D) and mealy from conidial heads. On Sabouraud agar, 

 colony elevated with central coremia, white to light rose. Gelatin liquefied. 



Cephalosporium spinosum Negroni, C. R. Soc. Biol. 113: 478-480, 1933. 



Isolated from a case of onychomycosis (toenails) in Argentina. Nails 

 show yellowish, spongy spots, without paronychia. 



In nails, hyphae septate, much branched. In cultures, sterile hyphae re- 

 pent, 1.5-2/i in diameter, producing coremia; conidiophores 1.3-1.5/a in diam- 

 eter, 27-30/x tall ; conidia in heads, ovoid, 4.9 x 3.26/x, smooth, hyaline. 



On Sabouraud honey agar, colony dirty gray and rough from coremia. 

 On Czapek agar, colony plane with about a dozen radial folds and numerous 

 secondary folds ; surface very spiny from coremia ; zonate with dirty, purplish 

 red color, margin dirty gray; reverse cafe-au-lait with reddish brown spots. 

 On Raulin's liquid with various carbohydrates, pellicle thick, white with red- 

 dish zones. No fermentation, acid produced with glucose, fructose, maltose, 

 sucrose, inulin, and galactose, somewhat in raffinose ; lactose becomes alkaline ; 

 nitrate reduced to nitrites. Milk not coagulated, gelatin not liquefied. 



It is uncertain whether the earlier case described by Negroni should be 

 referred here, although it is also possible that this is a more complete study 

 of the earlier case. One is greatly puzzled by the report of large septate spores 

 (suggesting Fusarium or closterospores of Epidermophyton in the earlier 

 paper). Is it possible that the septate spore belonged to the species of Epider- 

 mophyton causing the intertrigo of the toes? 



Cephalosporium sp. Negroni, Rev. Univ. Buenos Aires II, 29: 350-355, Figs. 

 53-56, 1931. 



Found in intertrigo of the toes and onychomycosis, in Argentina. [For 

 case history see Rev. Soc. Argentina Derm. Sifilol. 1929 or 1930.] Not patho- 

 genic for rabbit. 



In nails and scrapings, flexuous hyphae with branched conidiophores and 

 reniform spores. From cultures, vegetative hyphae, 3-4/^ in diameter, grouped 

 in funiculi, hyaline, septate, vacuolate, with fat globules. Conidiophores 

 hyaline, smooth, septate, 3/a in diameter, tapering upward, 40-65/* tall, verticil- 

 lately branched. Spores in a head at the tip, held together by a gel, 5-8 x 3-5/*. 

 Other fusiform spores 40 x 6/*, 1-4-celled, also seen in preparations. 



Colony on Czapek agar, velvety, dirty white with concentric zones; re- 

 verse slightly yellowed or not colored. 



Cephalosporimn Bogolepofla (Vuillemin) Dodge, n. comb. 

 Tilachlidium Bogolepoffi Vuillemin, Bull. Soc. Myc. France 28: 113-120, 

 PI. 6, 1912. 



Mycoderma Bogolepoffi Jannin, Les Mycoderma 188-190, 1913. 



