THE SECRETION DP FERMENTS BY THE LIVER CELLS 

 of ttie cives observable in ttiem Burino dieti 



It is well known that the bile contains several ferments that hâve a 

 digestive value, the most important of thèse, as pointed out by Pawlow ('), 

 is a ferment which acts upon those of the pancreatic juice greatly increasing 

 their efficacy and which, moreover, is présent in the bile in considérable 

 amount. This ferment can only be derived directly from the liver cells, 

 and therefore, signs of its manufacture should be demonstrable in cells by 

 ordinary histological methods. 



In a previous paper I ( 2 ) described the changes occurring in the fundus 

 glands of the Newt's stomach conséquent upon the production by them of 

 the ferments of the gastric juice, and similar changes can be seen to occur 

 in the fundus glands of mammals during secretory activity. I concluded, 

 therefore, that in the présent case it would be advisable to study the liver 

 of some mammal whose diet was not very différent from that of man him- 

 self. Undoubtedly the ape, or even the monkey, would hâve furnished the 

 best material, but I was constrained by the number of animais required and 

 the prohibitive price at which monkeys are sold in this country to seek 

 some animal that could be easily and cheaply obtained at ail times. I there- 



( 2 ) Carlier : Changes that occur in some cells of the Newt's stomach during digestion ; La 

 Cellule, t. XVI, and Proc. Roy. Soc. Edin., vol. XXII. 



(') Pawlow : The tvork of the digestive glands. Translation. London, 1902. 



