4 36 E. WACE CARLIER 



The nuclei appear still somewhat shrunken, though they stain more 

 deeply and contain nucleoli in increased number. The capillaries are less 

 dilated. 



Appearances presented by the liver cells 4 hours a/ter feeding. 



The cells whose outlines are distinct and appear neither swollen 

 nor wrinkled, though they exhibit rnuch vacuolation, especially around 

 the nucleus, and contain abundance of structureless material stained of 

 a dull red colour. The nuclei are plump with centrally placed nucleoli 

 and contain as much chromatin as in the resting condition. The capillaries 

 are narrow. 



Appearances presented by the liver cells S hours af 1er feeding. 



In the outer zone of the lobules the cell outlines are somewhat in- 

 distinct and irregular, the cytoplasm is not vacuolated to any extent and 

 contains little structureless material. Their nuclei are slightly wrinkled and 

 contain little or no deeply stained chromatin, but the nucleoli are large and 

 often either just under the capsule or in process of migration through it. 

 In the middle and inner zones of the lobules the cells présent the same 

 appearances as in the preceeding spécimens. The capillaries are dilated. 



Appearances presented by the liver cells 6 hours a/ter feeding. 



The changes noted in the outer zone of the lobules in the 5 hour 

 spécimens hâve now extended to the middle and inner zones, and, in 

 addition, the cytoplasm is much vacuolated even to almost complète dis- 

 appearance in some cases; very little structureless material is visible, that 

 présent staining of a bright scarlet colour. The nuclei are very pale, often 

 much wrinkled, and the nucleoli are large, migrating or lying in the 

 cytoplasm. 



In the outer zone many cells are swollen, clear and filled with glycogen; 

 they resemble in appearance those figured by Afanassiew (') in the dogs 

 liver after a copious meal of potato. The capillaries in this zone are narrow ; 

 elsewhere they are dilated. 



(') Afanassiew : Ueber anatomische Verànderungen der Leber wâhrend vet schiedener Thàtig- 

 keitsçuslànde ; Archiv f. d. ges. Physiol., B d 3o. 



