CONCERNING THE SECRETION OF FERMENTS BY THE LIVER CELLS 437 



Appearances présentée by the liver cells 7 hours aftcr fccding. 



Thc cells are very pale but contain somewhat more structureless 

 material; most of the nuclei are pale and wrinkled, but in the outer zone 

 of sorae lobules they are swollen and présent that clouded appearance 

 which I hâve elsewhere shown to be thc first stage in nuclear repair of 

 chromatin; nuclei in this condition are not numerous, but, where présent, 

 occur in groups of several together. The capillaries are dilated. 



Appearances pi'esented by the liver cells (S hours a/ter feeding. 



In thèse préparations the appearances presented by the cells resemble 

 closely those of the 7 th hour; but a few more nuclei in the outer zone of ail 

 the lobules exhibit clouding. 



Appearances presented by thc liver cells g hours after feeding. 



Much glycogen is présent in the cells; but the cytoplasm has still a 

 washed out look and contains some dusky vermillion stained structureless 

 material. In the middle and inner zones many of the nuclei are still wrink- 

 led, but in the outer zone ail the nuclei are swollen and clouded, as are 

 some of those along the outer border of the middle zone. The capillaries 

 are slightly dilated. 



Appearances presented by the liver cells 10 hours after feeding. 



Thèse spécimens closely resemble those of the u th hour, but more 

 nuclei of the middle zone are swollen and clouded. 



Appearances presented by the liver cells 11 hours after feeding. 



In the outer zone of the lobules the cells are full of glycogen, but con- 

 tain little structureless material which however still stains of a scarlet 

 colour, most of the nuclei of thèse cells are clearing or cleared up and 

 contain many deeply staining karyosomes, they are still somewhat swollen. 



In the middle and inner zones, the cells contain progressively less 

 glycogen, their nuclei are ail swollen and clouded, but some of those of the 

 middle zone are evidently becoming clearer. The capillaries are narrow. 



58 



