440 E. WACE CARLÏER 



Appearances presented by the liver cells 4 hours a/ter feeding. 



The cell outlines are not at ail distinct, especially in the outer zone of 

 the lobules, though the cells are well filled with fine ground glass-like cyto- 

 plasm; but in the middle zone it is arranged in fine spherules, whilst in the 

 inner zone it consists of coarse spherules; no vacuoles are présent in this 

 zone though a few small ones may be detected in the others. The struc- 

 tureless material is similar in amount and distribution to that which obtains 

 in the cells of the 3 rd hour spécimens. The nuclei of ail the cells contain 

 plenty of deeply staining chromatin with nucleoli of increased size. The 

 capillaries are not dilated. 



Appearances presented by the liver cells S hours a/ter feeding; fig. 5. 



The cell outlines are again indistinct, the finely spherular greyish 

 stained cytoplasm fills the cells with but few vacuoles, which, however, 

 increase in number towards the centre of the lobules. Hère and there an 

 irregular shaped nucleus may be seen, but in the majority of cases the 

 nuclei are resting, though a good many nucleoli are in progress of migra- 

 tion. The structureless material is similar in amount and arrangement to 

 that described in the 3 rd hour cells. The small cells bordering the portai 

 tracts are very conspicuous and their cytoplasm, which consists of very 

 coarse spherules, stains deeply; their nuclei are very wrinkled, small, 

 deeply stained and clouded to such an extent that the nucleoli are almost 

 invisible. The capillaries are not dilated. 



Appearances presented by the liver cells 6 hours af ter feeding. 



The small cells round the portai tracts no longer stain more deeply 

 than the others, though their nuclei are still somewhat clouded; elsewhere 

 the cell outlines are invisible, and the cytoplasm, which consists of small 

 spherules as in the small cells, is greatly vacuolated. Some nuclei are 

 swollen and stain less deeply, others are wrinkled and ail contain many 

 nucleoli, some of which are migrating. The structureless material is scanty 

 and diffuse in arrangement, no large clumps being visible. The capillaries 

 are dilated, especially towards the centre of the lobules. 



Appearances presented by the liver cells 7 hours a/ter feeding. 



The cells bordering on the portai tracts are indistinguishable from the 

 others except by their size, want of vacuolation and the largeness of their 



