CONCERNING THE SECRETION OF FERMENTS BY THE LIVER CELLS 44 5 



greyish colour except in the small cells round the portai tracts, where it is 

 still somewhat red. 



The spherules are much smaller in thèse cells than before, but are still 

 large in the middle and inner zones, though not so large as in the i hour 

 spécimens. The structureless material is présent in considérable quantity 

 and exhibits a tendency to aggregate into clumps. The nuclei of the small 

 cells hâve quite recovered and contain a considérable amount of deeply 

 stained chromatin. Those of the middle and inner zones are still clouded 

 and swollen, but not to the same extent. The nucleoli are large, less deeply 

 stained and often in process of migration into the cytoplasm. The blood 

 vessels hâve regained their normal size. 



Appearances présentée! by the liver cells 3 hours after feeding, fig. 8. 



The cell outlines are distinct, the cytoplasm, which consists of médium 

 sized spherules not very closely packed together, présents a slight pinkish 

 tint, contains scattered vacuoles and structureless material aggregated into 

 masses in considérable quantity. The nuclei of ail the cells are clear with 

 deeply stained chromatin, the nucleoli are large and migrating in considé- 

 rable numbers- The small cells round the portai tracts differ from the 

 others only in being less vacuolated and in having their spherules more 

 closely crowded together. The capillaries are small. 



Under a low magnification the whole lobule présents an uniform 

 appearance. 



Appearances présentée by the liver cells 4 hours after feeding. 



The cell outlines are well marked, the small cells surrounding the 

 portai tracts are very dense looking and stained deeply red, their nuclei are 

 showing signs of wrinkling. The larger cells are diffusely vacuolated and 

 contain less structureless material than in the preceeding spécimens, 

 although it is still présent in considérable quantity; their spherules are 

 smaller and less closely packed. The nuclei are in a state of rest though a 

 considérable number of large nucleoli are still in process of migration. 



Appearances presented by the liver cells S hours after feeding. 



The cell outlines are indistinct. In the small cells surrounding the 

 portai tracts the spherules are closely packed together and of large size, 

 their nuclei exhibit some clouding and are in an early stage of repair. In 



