444 



E. WACE CARLIER 



the remaining cells the cytoplasm, which consists of large spherules often 

 of ovoid form but not closely packed together, is diffusely vacuolated, very 

 pale in colour, and contains very little structureless material. On the whole 

 the cells throughout the lobules appear smaller than usual, which, by con- 

 trast, makes the capillaries appear larger than they really are. The nuclei 

 are wrinkled, pale and nearly exhausted, a few nucleoli are migrating. 



Appearances presented by the liver cells 6 hours afterfeeding, fig. 9. 



The cell outlines are indistinct and their vacuolated cytoplasmic con- 

 tents stain of a greyish colour. Glycogen is beginning to appear in the cells 

 of the outer zones, and the structureless material is again becoming more 

 abundant in a diffuse form, the spherules are more closely packed and of 

 large size, especially in the outer zone cells. The nuclei are very irregular, 

 and pale, with large migrating nucleoli, except in the outer zones, where 

 they are swollen and clouded. The capillaries are dilated, except in 

 this zone. 



Appearances presented by the liver cells 7 hours ajter feeding. 



The cell outlines are again distinct, and the cytoplasm which is greyish 

 contains more glycogen and is somewhat more vacuolated than previously; 

 the structureless material is increasing in amount and becoming aggregated 

 in the cells of the outer zone, the nuclei of which are only slightly clouded, 

 repair being almost complète. In the middle and inner zones the nuclei are 

 swollen and strongly clouded, especially in the latter; the nucleoli are 

 mostly of moderate size and a few are in process of migration. The small 

 cells bordering the portai tracts are resting, and their nuclei hâve fully 

 recovered. 



The capillaries are not dilated. In ail the cells the cytoplasmic sphe- 

 rules are still large, with deeply staining material adhering irregularly to 

 their periphera ; they are not closely packed together. 



The whole lobule stains homogeneously. 



Changes presented by the liver cells 6 hours afterfeeding. 



Thèse préparations resemble the preceeding ones in gênerai appearance, 

 but repair has gone further and is nearly completed. 



The cytoplasmic spherules are smaller and more closely packed, 



