446 E. WACE CARLIER 



plasm stains of a dirty pinkish yellow-brown, consists of small spherules 

 that are not at ail évident but exhibit a dull purple staining; their nuclei 

 are swollen and in many cases clouded, especially in the outer zone, the 

 nucleoli in some of thèse being very large with paler centres and a few are 

 migrating. 



Some of the most vacuolated cells in which the cytoplasm is reduced 

 to a mère network contain, adhering to this network, numerous minute dull 

 red granules which are also présent in the vacuoles in little clusters; they 

 evidently consist of precipitated sérum albumin as they are to be seen also 

 within the larger blood vessels. The small cells surrounding the portai tracts 

 are denser than those of the lobules and contain structureless material in 

 appréciable amount which the others do not. 



The nuclei of thèse cells are swollen and clouded; the capillaries are 

 dilated. 



Appearances presented by the liver cells 2 hows after feeding, fig. il. 



The cell outlines are indistinct; the cytoplasm, which is denser than 

 in the i st hour spécimens stains of a violet red hue, is full of large vacuoles 

 and contains some structureless material with a tendency to aggregate in 

 masses. The spherules are very small or absent and quite inconspicuous, 

 the nuclei are large, rounded and contain many incipient, intensely 

 staining karyosomes ; that is to say, they hâve nearly recovered from their 

 exertions. The nucleoli may be large and pale centred, but are mostly 

 small and homogeneously stained. 



The small cells round the portai tracts are very dense and consist of 

 small spherules closely packed together, they contain a few small vacuoles 

 and their nuclei are resting. The capillaries are not dilated. There is much 

 precipitated albumin throughout the préparations. 



Appearances presented by the liver cells 3 hours after feeding . 



The cell outlines are indistinct, the cytoplasm is less vacuolated than 

 in the preceeding spécimens and its dull purple spherules hardly distinguish- 

 able except in the small cells surrounding the portai tracts, where they 

 would appear to hâve remained unstained; more structureless material is 

 présent though it is not abundant and is scattered; there is still a con- 

 sidérable amount of precipitated albumin in the cytoplasmic meshes. The 

 nuclei are of normal size and appearance and are evidently resting, their 

 nucleoli are of moderate size only; the capillaries are not dilated. 



