454 E - WACE CARLIER 



statement on this subject, yet the différences observed are interesting in 

 themselves and are perhaps worthy of further attention. 



8. Some of the changes in the liver cells described by various authors 

 as characteristic of the action of certain poisons and diseases affecting thèse 

 organs, such as the growth in size of the nucleoli and their extrusion into 

 the cytoplasm, wrinkling of the nuclei and altérations in their staining 

 properties, and vacuolation of the cytoplasm, etc., are in reality merely 

 changes conséquent upon functional activity of the cells and owing to 

 the very striking nature of the changes thus produced, it is not at ail 

 astonishing, in the absence of any very definite knowledge on the subject, 

 that authors should hâve been misled into believing that they were in 

 présence of phenomena directly due to their experiments or to disease. 



In conclusion I would tender my hearty thanks to my laboratory 

 steward, Mr. C. Lovatt Evans, for the able assistance he has given me 

 both in preparing the spécimens for this research and in making the photo- 

 graphs that illustrate this paper. 



