THE KINETIC SYSTEM. 



By GEORGE W. CRILE, M.D. 

 (Read April 22, 19 14.) 



In this paper I formulate a theory which I hope will harmonize a 

 large number of clinical and experimental data, supply an interpre- 

 tation of certain diseases, and show by what means many diverse 

 causes produce the same end effects. 



Even should the theory prove ultimately to be true, it will mean- 

 time doubtless be subjected to many alterations. The specialized 

 laboratory worker will at first fail to see the broader clinical view, 

 and the trained clinician may hesitate to accept the laboratory find- 

 ings. Our viewpoint has been gained from a consideration of both 

 lines of evidence on rather a large scale. 



The responsibility for the kinetic theory is assumed by myself, 

 while the responsibility for the experimental data is shared fully by 

 my associates, Dr. J. B. Austin, Dr. F. W. Hitchings, Dr. H. G. 

 Sloan and Dr. M. L. Menten. 



Introduction. 

 The self-preservation of man and kindred animals is affected 

 through mechanisms which transform latent energy into kinetic 

 energy to accomplish adaptive ends. Man appropriates from envi- 

 ronment the energy he requires in the form of crude food which is 

 refined by the digestive system ; oxygen is taken to the blood and 

 carbon dioxid is taken from the blood by the respiratory system ; to 

 and from the myriads of working cells of the body, food and oxygen 

 and waste are carried by the circulatory system ; the body is cleared 

 of waste by the urinary system ; procreation is accomplished through 

 the genital system; but none of these systems are evolved primarily 

 for the purpose of transforming potential energy into kinetic energy 

 for specific ends. Each system transforms such amounts of poten- 

 tial into kinetic energy as are required to perform its specific work ; 

 but no one of them transforms latent into kinetic energy for the 



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