on ourselves, ascertained a psychotomimetie activity with 
a marked narcotic component with dosages of 0.5 to 1 
mg. The following paragraph is taken from a hitherto un- 
published record of the first experiment which the writer 
performed upon himself with LA 111 on 80.10.1947. 
10.00 h: Intramuscular injection of 0.5 ml of 1 per mille 
solution of LA 111 (=0.5 mg d-lysergic acid 
amide). 
11.00 h: Tiredness in the neck, slight nausea. 
11.05 h: Tired, dreamy, incapable of clear thoughts. 
Very sensitive to noises which give an unpleas- 
ant sensation. 
11.10 h: Desire to lie down and sleep. Genuine physical 
and mental tiredness, which is not experienced 
as an unpleasant sensation. Slept for 3 hours. 
15.00 h: Return of normal condition with full capacity 
for performing work. 
This action of d-lysergic acid amide was later confirmed 
by the comparative systematic investigation of H. 
Solms.” 7? He describes the action as follows: LA 111 
induces indifference, a decrease in psychomotor activity, 
the feeling of sinking into nothingness and a desire to 
sleep. . . until finally an increased clouding of conscious- 
ness does produce sleep. 
Clinical investigations have been initiated with d- 
isolysergic acid amide but no results are available yet. 
Upon taking 2 mg. of isoergine himself, the writer ex- 
perienced tiredness, apathy, a feeling of mental empti- 
ness and of the unreality and complete meaninglessness 
of the outside world. 
Klymoclavine and lysergol elicit an excitation syn- 
drome in various animals that is caused by a central 
stimulation of the sympathicus.* The results of clinical 
testing are not, as yet, available. 
[ 209 | 
