114 Chittenden and Slake — Influence of Arsenic and Antimony. 



diminution in the liver fat, and a complete disappearance of both 

 glycogen and sugar. 



While these experiments are far too few in number to generalize 

 from, yet it would appear that small doses of antimonious oxide long 

 continued tend to increase body weight, and particularly the weight 

 of the liver. Further, the increase in liver weight is accompanied 

 by an increased percentage of fat and a slight increase of liver 

 glycogen. 



With corresponding doses of arsenious oxide, on the other hand, 

 the results would indicate a diminution in body weight, likewise a 

 diminution in the weight of the liver and also in the amount of liver 

 fat. As regards glycogen, two of the results show an increased 

 amount in the arsenical livers, while in one experiment there was a 

 total disappearance of glycogen. On the other hand, as Experiment 

 No. I indicates, there may be, with small doses of arsenic, a very 

 pronounced fatty degeneration of the liver, accompanied by an in- 

 creased liver weight and an increase in the percentage of liver 

 glycogen. 



