Therapeutic Agents on Amylolytic and Proteolytic Action. 65 

 Thallin sulphate. 



Thein and Cafein. 



Fibrin 

 digested. 



89-5 per cent. 



74-8 

 82-1 

 41-6 



Relative 

 proteolytic action. 



100-0 



84-7 ■ 



91-8 



46-5 



These results show that autipyrin has a decided inhibitory influ- 

 ence on the action of the proteolytic ferment, and that when present 

 to the extent of 3'0 per cent, it practically stops all digestive action. 

 Antifebrin has also an inhibitory action, perhaps equal to that of anti- 

 pyrin, but owing to its greater insolubility in acid fluids large per- 

 centages of the substance could not be tested. 



Uretban has only a slight retarding action, even when present to 

 the extent of 5 per cent. 



Paraldehyde and thallin sulphate both show a very decided stimu- 

 lating action when small fractions of one per cent, are present, the lat- 

 ter, particularly, causing a much larger amount of fibrin to be di- 

 gested than in the control experiment. 



Thein and cafFein both show an inhibitory influence on the ferment, 

 that of cafFein being much greater than that of thein. 



On the proteolytic action of trypsin in an alkaline solution, two 

 substances only were tested, antifebrin and paraldehyde. The ex- 

 periments were conducted in the same manner as with pepsin-hydro- 

 chloric acid, except that a solution of trypsin in 0*3 per cent, sodium 

 cai'bonate was employed in place of the pepsin-acid, and the mixture 

 warmed for a longer time at 40° C. Following are the results ob- 

 tained, showing a much more pronounced inhibitory action on this 

 ferment than on pepsin. 



Per cent, of 

 substance. 







Undigested 

 residue. 



0-2 antifebrin. 

 1*0 



0-2 paraldehyde 

 20 



Trans. Conn. A.cad., Vol. VIII 



0-159 gram. 



0-368 



0-741 



0-368 

 0-959 



Fibrin 

 digested. 



84-1 per cent. 



63-2 



25-9 



63-2 



4-1 



Relative 

 proteolytic action. 



1000 



75-1 



30-8 



75-1 



4-9 



Nov., 1888. 



