48 R. H. Ghittende7i — The Influence of JJrethan, Paraldehyde, 



III. Influence of Antipyrin ; — from experiments made by H. F. Adams, 



Ph.B. 



Previous experiments* with antipyrin, made in this laboratory, 

 have shown that this drug, when introduced into the stomach of 

 healthy rabbits, has little, if any, noticeable influence on the excre- 

 tion of carbonic acid or on the body temperature, except in the 

 case of toxic doses. Coppola,f likewise, found that the subcu- 

 taneous introduction of 0-1 to 0-3 gram of antipyrin in the case of 

 dogs led to a reduction of body temperature of only 0*25 to 0-6 of a 

 degree, while 0*3-0*4 gram of the di'ug was without any noticeable 

 influence upon the excretion of urea. In fever patients, F. Muller,J 

 however, had previously noticed a diminution in the excretion of 

 nitrogen under the influence of antipyrin, while in the case of healthy 

 men the excretion was afiected but very slightly, if at all. Jacubo- 

 witsch,§ likewise, had noticed in experiments on healtliy and fevered 

 children that the use of antipyrin led to a diminution both in the 

 quantity and specific gravity of the urine, and also a diminution in 

 the quantity of uric acid, phosphoric acid, sulphuric acid and of 

 chlorides. L. Riess,|| by carefully conducted experiments on nine 

 typhus fever patients, found as a j)rincipal result that antipyrin in 

 doses up to 12 grams per day diminished considerably the excretion 

 of nitrogen, the diminution ranging in six series of experiments from 

 2*5 to 24'7 per cent. Umbach,^ likewise, has studied the influence 

 of antipyrin on the excretion of nitrogen, both on a dog and on him- 

 self, and he found that with a definite diet the excretion of nitrogen 

 sank, under the influence of 4 grams of antipyrin, in two days about 

 2 grams, equal to 4 grams of urea. The uric acid excretion, however, 

 was not materially afiected. 



In spite of these manifold experiments, we have deemed the matter 

 of sufiicient importance to warrant further study, especially with a 

 view to the action of the drug on the metamorphism of nitrogenous 

 matter in the healthy organism. Tlie experiments were therefore 

 tried upon a healthy man with a body weight of 77 kilograms, and 



* Chittenden and Cummins. Studies, vol. ii., p. 231. 



f Abstract in Jahresbericht fiir Thierchemie. 1885, p. 98. 



X Abstract iu Jahresbericht fiir Thierchemie. 1884, p. 242. 



§ Abstract iu Jahresbericht lur Thierchemie. 1885, p. 444. 



II Archiv fiir experim. Pathol, u. Pharm. xxii, 127 ; also Abstract in Jahresbericht 

 fiir Thierchemie. 1886, p. 417. Ueber stickstoffausscheiduug bei antipyretischer 

 Fieberbehandlung. 



^ Ueber den Einfluss der Antipyrins auf die stickstoffausscheidung. Abstract in 

 Jahresbericht fiir Thierchemie. 1886, p. 418. 



