Antipyrin, and Antifebrin on Proteid Metabolism. 

 Without Paraldehyde. 



47 



Throughout the experiment, the dog appeared perfectly well, and 

 at no time showed any symptoms of nausea. Neither was there any 

 special hypnotic action noticeable. 



The average of the results shows plainly that the drug has little, 

 if any, action on proteid metabolism. Under the influence of the 

 paraldehyde there was a slight increase in the amount of water 

 excreted. Bokai * has stated that the urinary secretion is slightly 

 increased by paraldehyde. In our experiment, however, the diuretic 

 action is not great. As regards the excretion of nitrogen, there is a 

 slight diminution to be seen in the paraldehyde period. There is 

 also a corresponding decrease in the excretion of phosphorus. The 

 three periods, however, show such close agreement in results, it is 

 obvious that, under the conditions of this experiment, paraldehyde 

 has not exerted any special influence on proteid metabolism. 



According to the experiments of Quinquad and A. Henocque,f 

 paraldehyde causes a diminution of body temperature, and at the 

 same time a very noticeable falling off* in the excretion of carbonic 

 acid ; thus, according to one of Quinquad's experiments, a dog after 

 receiving by hypodermic injection 8 c. c, of paraldehyde gave off" 5-5 

 grams of carbonic acid, while it expired during the same time, three- 

 fourths of an hour after the injection, only 1*96 grams of carbonic 

 acid. 



* Ueber die physiologische Wirkung des Paraldehyds. Centralblatt fur die medicin- 

 ische Wissenschaften. 1887, p. 412. 



f Abstract in Jahresbericht fiir Thierchemie. 1884, p. 374. 



