1 6 Chittenden Mid Lambert — Experhnents on the 



scope, sections showed the cell bodies strongly granulated, with their 

 outlines mostly clear, but in places broken down. 



There was also an infiltration of pus cells around the blood vessels. 

 The kidneys were normal in size and appearance, with non-adherent 

 capsules. Under the microscope, however, all the conditions charac- 

 teristic of acute parenchymatous nephritis were to be seen. The 

 epithelial cells of the malpighian tufts were proliferated, so much so 

 as to compress the vessels. Both convoluted and straiglit tubules 

 had their cells swollen, granular and broken down. The stroma was 

 normal. Some adipose tissue in the pelvis of the kidney was infil- 

 trated with pus cells. There was also considerable detritus between 

 the papillae. The bladder was empty and contracted. In the abdom- 

 inal cavity there was about 30 c.c. of a coaguiable, clear fluid. The 

 stomach was full of food, the intestines empty. No foeces in colon 

 and rectum. No signs of congestion in the alimentary tract, except 

 in the rectum, where there were red blotches which proved to be the 

 beginning of inflammation and infiltration of pus cells. The animal 

 appeared to have died from suppression of urine. 



Experiment IX. 



In this experiment, one large dose of uranium (TO gram of the 

 nitrate) was given by mouth on June 27th, at 4.30 p. m. On July 5th. 

 the animal was still alive, but weak and emaciated. There were no 

 symptoms other than those already described. Owing to lack of 

 time we were not able to continue the experiment, but wishing to see 

 any changes which might have occurred in the organs the animal was 

 chloroformed and a post mortem made. On June 28th, the urine 

 passed contained some albumin, but no sugar; on July 1st, considera- 

 ble albumin, but still no sugar. 



The liver was found to be small but not congested. The cell sub- 

 stance, as seen iinder the microscope, was collected into small gran- 

 ules. Nuclei and nucleoli were quite distinct. Kidneys had non- 

 adherent capsules, but they were congested and the cortex looked 

 striated. Under the microscoi^e, the epithelial cells of the glomeruli 

 were seen to be swollen and proliferated. In the convoluted tubes, 

 the cells were slightly swollen and granular and occasionally broken 

 down. The straight tubes were also broken down in places and con- 

 tained cast matter. The stroma was normal. Stomach was filled 

 with food, while the intestines were entirely empty. Peyer's patches 

 were swollen and infiltrated with pus cells. The cgecum was par- 

 tially filled witli matter and the end of it looked honey-combed. It 



