Physiological Action of Tlraniimi Salts. 1 3 



Sections under the microscope showed no pathological changes. The 

 kidneys were congested. Under the microscope, the epithelial cells 

 were proliferated and occasionally the tufts wei-e seen slightly com- 

 pressed by these proliferating cells and detritus. The convoluted 

 tubules showed swollen and granular cells, even broken down, in 

 places. In the straight tubules, the cells were also swollen and gran- 

 iilar and sometimes were detached from the tubes. In places, there 

 was cast matter and detritus in the tubes. The stroma was normal. 

 Hence, here, as in many of the preceding experiments, it is a case of 

 acute parenchymatous nephritis. The stomach was full of undi- 

 gested food and apparently normal ; the duodenum was congested 

 and the small intestines throughout were nearly empty, except for a 

 little mucus. The bladder had in it about 10 c. c. of urine, which 

 contained a trace of albumin but no sugar. 



Experiment VII. 



An albino rabbit. A single dose of 0*3 gram of uranyl nitrate 

 was given in a gelatin capsule by mouth on June 13th. Outside of 

 changes in the urine there were no symptoms whatever until the 17th, 

 when in the early morning the animal was found weak and power- 

 less, all motor power coinpletely gone. It rapidly grew weaker and 

 died in the afternoon of the same day. 



The right side of the heart was found much distended. The lungs 

 were normal, the liver small and congested. Kidneys were also 

 small and congested and of a cloudy appearance. Microscopic exam- 

 ination showed acute parenchymatous nephritis. Stomach was full 

 of undigested food, but the intestines were empty. Both appeared 

 normal. 



On June loth, 160 c. c. of alkaline urine were passed, of specific 

 gravity 1023. It contained 0-748 gram of albumin and 1-069 grams 

 of sugar. On the 16th, 30 c. c. were passed of 1022 specific gravity 

 and containing 0-412 gram of albumin and 0-354 gram of sugar. 

 On the 17th, no urine was passed and on making the post mortem the 

 bladder was found empty. 



With this rabbit, an attempt was made to ascertain how much 

 carbohydrate matter there was in the liver at the time of death. 

 40 grams of the sampled and finely ground liver were thoroughly 

 extracted Avith boiling water (continuous extraction for three days), 

 frequently replaced. The several decoctions were ultimately united 

 and finally brought to a volume of 500 c. c. Two portions of 200 c. c. 

 each were placed in suitable flasks and suflicient hydrochloric acid 



