Physiological Action of Tlranium Salts. ' 11 



bladder contained a few cubic centimeters of urine, which had in it 

 considerable sugar and some albumin. 



The most noticeable feature of this experiment was the suppression 

 of urine. 



Experiment IV. 



In this experiment, a large white buck was used and the uranium 

 was administered in capsules as follows : 



0-225 



There were no symptoms of toxic action until the morning of the 

 20th. The rabbit was then dull and weak. He trembled violently 

 as he hopped about; the hind legs appeared j^artly paralyzed. The 

 pupils were dilated and the appetite gone. On the 21st, weakness 

 was still more pronounced. Any movement was accompanied by 

 tremblings and great difficulty was experienced while walking, in 

 making the dilferent movements correctly. There was severe diar- 

 rluea and the animal showed extreme emaciation. On the 22d, the 

 diarrhoea had passed into an involuntary defecation more or less 

 continuous. The animal was too weak to move and lay all the fore- 

 noon breathing heavily, though the number of respirations per minute 

 did not go much beyond normal, 45-54 per minute. On the afternoon 

 of this day, two days after the last dose of uranium had been admin- 

 istered, the animal appeared stronger, the involuntary defecations 

 had ceased, though a loose diarrhoea still continued, and the animal 

 appeared to have recovered the use of its locomotive muscles. On the 

 23d, however, the animal was again unable to move and finally died 

 at noon, the diarrhoea having continued more or less up to death. 



During the last three days there was complete suppression of 

 urine, but on the 20th, 59 c. c. of urine were passed, of specific gravity 

 1022, and which contained 0-656 gram of sugar. 



On post-mortem examination, the heart was found to have stopped 

 in diastole and engorged with blood. The lungs were congested. 

 The kidneys had non-adherent capsules and the cortex and medulla 

 showed severe congestion. The stomach contained no food, but con- 

 siderable tenacious mucus. The small intestines from duodenum to 

 caecum were very much congested. 



