Physiological Action of Uranium Salts. 



9 



The kidneys were very mncli diminished in size and extremely con- 

 gested. Sections showed that the epithelial cells of the malpighian 

 tul'ts were not swollen or prolil'erated, though in some places the 

 tufts of vessels were slightly compressed by detritus. The cells of 

 the convoluted tubules were swollen, granular and broken down or 

 gone entirely, as were also the cells of the straight tubes, the latter 

 being also filled in places with casts and detritus. The vessels be- 

 tween the tubes were filled with blood. The stroma was swollen 

 and infiltrated with pus cells and in j^laces there were extravasations 

 of blood. 



Brain and cord were slightly congested, but otherwise normal. 



Examination of the table of urine tests shows that sugar appeared 

 first in the urine, but continued only lor three days, while albumin 

 showed itself immediately after the first appearance of the sugar and 

 continued throughout the experiment. The amount of ui'ine voided 

 grew gradually smaller as the animal began to feel the full effects of 

 the uranium, 



Ex23erinie7it II. 

 In this experiment, uranium was given as indicated in the follow- 

 ing table, and the urine examined each day. 



On June 4th, the animal began to show weakness, particularly 

 noticeable in his hind legs, but this disappeared and the animal 

 Trans. Conn. A.cad., Vol. VIII. 2 Nov., 1888, 



