112 Chittenden and Blake — Influence of Arsenic 



Experiment V. 

 Action of antimony on a fowl. 



Period of dosing. 

 May 20-24, 0-2 grain Sb^Os daily. 



" 25-31, 0-4 " 



June 1- 7, 0-6 " " " . 



" 8-15, 0-8 " " " 



" 16-19, 1-0 " " " 



18*4 grains. 



^, control fowl. B, antimony fowl. 



Body weight May 20, 1701 grams. 1757 grams. 



" " June 20, 1644 " 1814 



-57 +57 



Weight of liver June 20, 34'177 grams. 35'440 grams. 



Determination of fat in liver. 



A, control, 9*477 grams liver gave 0-3890 gram fat, ^=. 4'10 per cent. 



B, antimony, 9-579 " " " 0-5088 " " = 5-31 " 



+ 1-21 per cent. 

 The appearance of the liver in B indicated fatty degeneration. 



Determination of glycogen and sugar. 



A. B. 



Weight of liver used, 24-700 grams. • 25-871 grams. 



Glycogen A, control. 



Volume used Equivalent Equivalent Total Per 



for redaction. Weight Cu. in dextrose. in glycogen. amount. cent. 



25 c. c. 0-2253 gram. 0-1160 gram. 0-1044 gram. 0-8352 gram. 3-38 



25 0-2253 01160 01044 0-8352 3-38 



Glycogen B, antimony. 

 25 c. c. 0-2480 gram. 0-1281 gram. 0-1153 gram. 0-9224 gram. 3-56 



25 0-2479 0-1280 0-1150 0-9200 3*55 



Sugar A^ control. 



25 c. c. 0-0360 gram. 0'0189 gram 0-1512 gram. 0-61 



25 00360 00189 0-1512 0-61 



Sugar B, antimony. 



25 c. c. 0-0383 gram. 0-0200 gram. 0-1600 gram. 0-62 



25 0-0372 00195 0-1560 0-60 



100 grams of breast muscle gave I'S miUigrams Sb. 



In this experiment, there was pronounced fatty degeneration of the 

 liver in the antimonial fowl. Further, as in the last experiment, there 

 was apparently a slight increase both in body weight and in the 

 weisrht of the liver. 



