108 Chittenden and Slake — Influence of Arsenic 



ture contain 2 per cent. H^SO^, boiling for two hours to convert the 

 sugar wholly into dextrose, and then, after neutralization of the acid 

 fluid and diluting to 200 c. c, testing its reducing power by Allihn's 

 method. 



Experiment I. 



Action of arsenic on a fowl. 



Period of dosing. 



May 20-24, 0-1 grain AsoOa daily. 



" 25-31, 0-2 " " " 



June 1-15, 0-3 " " " 



6*4 grains. 



A, control fowl. B, arsenic foivl. 



Body weight May 20, 1814 grams. 1814 grams. 



" " June 16, 1871 " 1686 " 



+ 57 -128 



Weight of liver, June 16, 28-378 grams. 34-635 grams. 



The liver of B, showed unmislakedble signs of fatty degeneration. 



Determination of fat in liver. 



A. control, 9210 grams liver gave 0-3347 gram fat, = 3-63 per cent. 



B. arsenic, 13848 " " " 1-8561 " " = 13-40 " 



+ 9-77 per cent. 

 Determination of glycogen and sugar. 



A. B. 



Weight of liver used, 20-167 grams. 20-787 grams. 



Glycogen A, control. 



Volume Equivalent Equivalent Total Per 



used. Weight Cu. in dextrose. in glycogen. amount. cent. 



25 c. c. 00744 gram. 0-0380 gram. 0-0342 gram. 02736 gram. 1-35 



25 00727 0-0371 0-0334 0-2672 1-32 



Glycogen B, arsenic. 

 25 c. c. 0-1720 gram. 0-0879 gram. 0-0791 gram. 0-6328 gram. 3-04 



25 0-1713 0-0875 00787 0-6296 3-02 



Sugar A, control. 



25 c. c. 0-0299 gram. 0-0159 gram. 0-1272 gram. 063 



25 0-0332 0-0176 0-1408 0-69 



Sugar B, arsenic. 



25 c. c. 0-0185 gram. 0-0102 gram. 0-0816gram. 039 



25 0-0162 0-0091 0-0728 0-35 



100 grams of breast muscle from £ gave 04 milligram of ^s. 



In this experiment, then, we have as the apparent result of the long- 

 continued feeding of arsenic a loss of body weight, a decided increase 



