Absorption of Nickel and Cobalt. 151 



Following are the amounts of absorbed cobalt found in experi- 

 ment II : 



Total weight Weight Co per 100 



of organ. of Co. grams of tissue, 



grams. milligrams, milligrams. 



Stomach and contents. 81-75 57-5 70-34 



Small intestines - 43-90 13-8 31-44 



Large intestines... 26-40 40-3 15210 



Cgecum .-- 154-00 302-5 196-43 



Liver.. .-.. 45-75 8-9 19-43 



Kidneys 10-30 lost 



Heart.. 8-80 0-7 7-95 



Lungs 5-82 0-9 15-46 



Muscleof legs- 100-00 1-9 1-90 



Muscleofback 27-45 1-5 5-46 



Brain 8-75 



a • 1 ^ Q «Q k 0-8 6-45 



Spmal cord - 3-63 ) 



Considering the large amount of cobalt nitrate administered, the 

 extreme solubility oi the salt, and the length of time intervening 

 between the iirst and last dose, it is somewhat surprising that the 

 amount absorbed was not greater. Evidently a large portion of the 

 cobalt passes directly through the alimentary canal, pi'obably com- 

 bining with the proteid matter of the food to form an insoluble and 

 indigestible compound. 



Experiment III, with nickel. 



A black and white doe of 4 kilos, body weight was dosed as fol- 

 lows : 



Oct. 15, 0-200 gram nickel nitrate. 



" 16, 0-400 " " 



" 17, 0-600 " 



-' 18, 0-800 " 



" 19, 0-500 " " " 



2-500 grams. 



On the morning of the '20th, the animal was found dead, the only 

 noticeable symptoms having been general weakness, loss of appetite 

 and diarrhoea. The loss of body weight was quite pronounced, 

 amounting in the six days to 1-4 kilos. The urine was entirely free 

 from albumin and sugar. There was a little inflammation of the 

 stomach. In this experiment, the toxic action would appear to have 

 been greater than that of the cobalt in the preceding experiment. 

 The distribution of the absorbed poison was as follows ; 



