152 R. H. Chittenden and C. Norris — The Relative 



Total weight Nl per 100 grams 



of organ. Weight of Ni. of tisaue. 



grams. milligrams. milligrams. 



Stomach and contents 115-00 12-2 10-68 



Small intestines _.. 67-87 11-4 16-88 



Large intestines 37-45 3-9 10-41 



Cajcum 190-00 9-4 4-95 



Liver - 87-50 5-1 5-83 



Kidneys 18-85 0-8 4-24 



Heart .-. • 8-90 1-3 14-60 



Lungs 14-15 0-9 6-36 



Muscle of legs 292-00 1-2 0-41 



Muscle of back-.. 129-00 3-8 2-95 



Brain... 875 21 2400 



Spinal cord 500 1-0 20-00 



Spleen-..- 2-00 0-6 30-00 



The amount of nickel found in the alimentai-y tract is naturally 

 not so large as in the case of cobalt, where the final doses were larger 

 and the diarrhoea not so bad. Of the absorbed nickel, the distribu- 

 tion is essentially the same as with cobalt. The amount in the kidneys 

 and liver is not as large as would be expected from the size of the 

 doses and the soluble character of the salt. It suggests that only 

 a small portion of the salt given is absorbed, and that elimina- 

 tion goes on with comparative slowness. Quite striking is the 

 peculiar distribution of the nickel in the muscle tissue, the amount 

 in the muscles from the back being seven times as large as in the leg 

 muscles. The same peculiarity is likewise noticeable with cobalt. 

 Also noticeable is the comparatively large amount in the brain and 

 spinal cord, more of the poison in proportion to the weight of the 

 organ being found here than in either the liver or kidneys. 



Experiment lY^ with cobalt and nickel. 



In this experiment, two rabbits of approximately the same body 

 weight were dosed with nickel and cobalt respectively as follows : 



Nov. 1, 



