,,„ E WACE CARLIER 



410 



sécrétion leaves the cell, which it does in a liquid and unstainable form. 

 I hâve not however been able to distinguish any vacuoles in the protoplasm 

 for the storage of the sécrétion, nor any intracellular canals or ducts for its 

 escape, though such canals undoubtally exist in the case of the oxyntic cells 



of mammals. 



The protoplasm of the cells appears condensed and stains pale blue, 

 this condensation would seem to be due rather to the disappearance of the 

 granules and discharge of the fluid in the vacuoles than to a reconstruction 

 of the protoplasm. I agrée in this rather with Nicolas^' than with Langley "■. 

 Where granules are still présent, they lie in vacuoles in the protoplasm. 



The nuclei are larger at this time than in the preceding case, the ave- 

 rage of a number of measurements being 1 1 ,85 !^- X 1 3,36 i'-, they also appear 

 somewhat less angular. The nuclear membrane appears thickened owing 

 probably to the chromatin spreading itself out upon its inner surface. 

 There is usually a great dearth of chromatin deeper in; what little there is 

 is pale and has a washed out appearance. 



The lanthanin granules hâve in the majority of cases undergone no 

 change, but in a few nuclei they stain of a deeper tmt and are not crowded 



together. 



The nucleoli vary a good deal in size but are not numerous, they stain 

 of the same venous tint; the larger ones may often be seen lying quite 

 close to the nuclear membrane and some of them may even be seen in the 

 act of passing through the nuclear wall into the protoplasm. 



44 Hours afterfood. — Plate I, fig. 3 and 4. 



When opened remains of the worm were found in the stomach. 



At this stage the cells are much larger and the gland lumen correspon- 

 dmgly reduced in size. The zymogen granules are numerous though not 

 crowded together, they are usually of médium or small size, the larger ones 

 being most numerous near the apices of the cells, still in very many cells, 

 it is impossible to locate granules of any particular size in any definite 

 part. The granules average 1 —2 ,,. in diameter. 



The cell protoplasm hardly stains at ail, or exhibits a pale reddish grey 

 tint showing that it has taken up alkaline material from the blood. The 



cell envelope stains pale blue. 



The nuclei appear extremely wrinkled and contain very little chromatin, 

 that présent has a washed out appearance and stains feebly blue. Average 



