THE NEWTS STOMACH DURING DIGESTION 447 



lymph spaces between them crossed by short cell bridges. The cernent sub- 

 stance is confined to a cernent net that lies at or near the tips of the mucigen 

 cups. The protoplasm at the attached end of the cells is in very sinall amount 

 and appears to contain, in some cases at any rate, a few tiny red-staining 

 granules similar to thèse found between the nucleus and the mucigen 

 cup. Thèse cells are very prone to divide karyokinetically and from them 

 the surface cells at any rate probabl)' arise (Warburg", Bizzozero ', 

 Heidenhain ", etc.). They correspond to the cells, recently described in 

 the cat's stomach by Bensley' as indulinophilous cells, that hâve been 

 known to me for several years as staining intensely sky blue with methyl 

 blue. They suiTOund the narrowest portion of the lumen of the oxyntic 

 glands in the newt as in the cat. 



The changes occurring in thèse cells during functional activity resemble 

 very closely those described in the case of the surface cells and can there- 

 fore be dismissed in a few words. 



The mucigen cups at first become somewhat larger than during rest, 

 but they quickly thereafter diminish in sizc and contents, remaining small 

 till about the seventh or eighth hour àfter food, when they may be seen 

 to be again increasing rapidly and attain their normal size at the ninth or 

 tenth hour. 



The red granule zone seems to take longer to exhaust than in the case 

 of the surface cells, there being still some granules in it at the end of the 

 third hour; the reproduction of thèse granules also appears to be tardy, 

 a few only remaking their appearance at the end of the ninth hour. The 

 nuclear changes are very similar to those in the surface cells but the 

 chromatin begins to show a mixture of red and blue reaction as early as 

 2 1/2 hours after food, becoming very red at the third hour and continuing 

 to stain of a reddish tint till the end of the fifth hour. In this case the red 

 reaction lasts even longer than in the ox3mtic cell nuclei, and this affinity 

 for the red dye is especially marked in the chromosomes of the karyokinetic 

 figures ofwhich. there are many; especially in the pyloric glands during 

 the 3'^ 4"" and 5"' hours. 



The lanthanin granules undergo precisely the same variation as m the 

 surface cells, as do also the nucleoli which increasein size to the end of the 

 fourth hour at which time extrusion would appear to begin, and they regain 

 their normal size about the end of the 9"' hour. 



