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E. WACE CARLIER 



completety restored. I think therefore that one must look to the nuclear 

 juice to find the eaiiiest indication of the synthesis by which chromatin 

 is built up from simpler compounds. 



Another interesting point is the fact that so long as the nuclei are in 

 an exhausted condition no mitosis occurs, but that as soon as repair has 

 reached a certain stage a few nuclei exhibit mitotic figures which increase 

 steadily in number until the cells are fully restored when its maximum is 

 reached, to again diminish and cease altogether when the nuclei again 

 become exhausted. 



Furtlier cells called uponto secrète during nuclear division do so exactly 

 as if no mitosis were going on and this sécrétion proceeds along with the di- 

 vision both occurring at the same time, the chromatin of the mitotic figure 

 showing exactly the same changes in appearances and colour reaction exhi- 

 bited by the karyosomes of the cells that are not dividing, the only appa- 

 rent différence being that owing to the desappearance of the nuclear enve- 

 lope no nucleoli are formed, the split off albuminous material being disposed 

 of directly by the cytoplasm. 



Lastly I would thank the late Prof. Rutherford for his courtesy and 

 kindly support during the progrès of the research and D" J. H. Milroy 

 for valuable assistance in working out the chemical side of the question. 



