SS JOURNAL OF THE 



The formatian of Helicin according^ to the following: 

 equation would be an example of this method: CgHt- 

 ClO.fC H30)4 -h C7H3O.K -h 4aH.O = Ci3Hi60-+KCl-h 

 4CzH5C2H30,. 



Emil Fischer^ has recently discovered a new method 

 of formin^f these derivatives, and has prepared com- 

 pounds of methyl, ethyl, propyl, amyl, isopropyl, 

 alh'l and benzo}^ gducose. Also analoo^ous compounds 

 of arabinose, methyl-arabinoside. 



These do not reduce Fehlino-'s solution; they break 

 up into g-lucose and the corresponding alcohol on treat- 

 ment with dilute acids or ferments, and behave in 

 every way similarly to the natural ^lucosides. 



I proposed to form them by the action of alkyl 

 iodide upon the sodium o-lucosate according- to the fol- 

 lowing- equation: 



C^Hi.NaO, + C,HJ - C,H,,0,.C,H, + Nal. 



For this experiment, the ethyl g-lucoside was chosen, 

 as the materials for its preparation were already on 

 hand, and because in all probability the method would 

 work as well for this one as an}' other member of the 

 series. 



The insolubility of sodium g-lucosate in all neutral 

 anhydrous mediums on hand, was recog-nized at the 

 outset of this work to be a g-reat obstacle in the way 

 of the successful operation of the method. 



As a preliminary test, 15 g-rs. of anhydrous g-lu- 

 cose was taken and g-ently boiled for some time 

 with 150 c. c. of about 97 per cent, alcohol. This so- 

 lution, when saturated, was poured off into a largfe flask 

 in which the precipitation was to be made, and kept 

 warm by standing- in a water bath, in order to prevent 

 the g-lucose from crystallizing". 



2. Ber. 26, 2400. 



