(C s H, O s )„ 

 glycogen 



JtH.-iPO, 



H— C— OP0 3 Hj 



H— C— OH 



H— C— OH 



I 

 H— C 



ALCOHOLIC FERMENTATION 



C fi H,,O s 

 glucose 



H— C- 



I 

 ==; HO— C- 



glucose-1-phosphate 



it lori-ester) 



OH 



-H 



OH 



C 6 H,,0 6 

 fructose 



ir«-ATP 



H : C— OH 

 I 

 C— (OHH 



HO— C— H 

 I 

 H— C— OH 



H— C 



() 



H,C— OPO.H. + ADP H 2 C— OPO,H, * VDP 



glucose-6-phosphate 

 (Robison-ester) 



fructose-6-phosphalc 

 (Neuberg-ester) 



H 2 C— OPO,H 2 



fr >|?'ose.l,6-diphosphate 

 (Harden- Young-ester) 



dihydroxyacetone-phosphate 



CtOHt— , 



I P 



HO— ( 



H— C— (HI 

 I 



H— C 1 



I 

 HsC— OP0 3 H 2 + ADP 



CH .()PO,H 

 I 

 C = 



1,3-diphosphoglyceric acid 

 (Negelein-ester) 



3-phosphoglyceric 

 i Nilsson-ester) 



2-phosphogIyceric acid 



phosphopyruvic acid 

 (enol-) 



|CO,.| ■+ I HaCHO 

 carbon acetaldehyde 

 dioxide 



— CHOII 3-phosphoglycer-aldehydc 



(Fischer-ester) 

 CH 2 OPO,[|. 

 Jt + coenzyme H-HaPOj 

 = C— OPO3H. t 



I 

 CHOH + dihydrocoenzyme 



CH 2 OPOaH 







// 

 C— OH 



CHOH+ I ATP I 



I 



CHsOPOaHs 



Jt 



COOH 



I 

 CHOPOaH a 



I 



CH 2 OH 

 Jt 

 COOH 



COPOaHs 



COOH • 



1 I — I 



c=o+ |atp1 



• dihydro 



CH, 

 pyruvic 



CH,CII..OII I coenzyi 



Figure 13. — Survey of alcoholic fermen- 

 tation, 195c llif "well-known scheme of 

 alcoholic fermentation" according to Albeit 

 Jan Kluyver (1888-1956). presented before 

 the Society of Chemical Industry in the 

 Royal Institution, March 7, 1951. In 

 Chemistry & Industry, 1952, page 136 II.. 

 Kluyver restates that " . . . the fermentation 

 of one molecule of glucose is indissolulily 

 connected with the formation of two mole- 

 cules of adenosine triphosphate (ATP) out 

 of two molecules of adenosine diphosphate 

 (ADP)." 



ethyl alcohol 

 L90 BULLETIN 240: CONTRIBUTIONS FROM THE MUSEUM OF HISTORY AND TECHNOLOGY 



