|" i Inn, .mil m, 1 1 ketec I mule i trade na I IKS like Sarkolyt, 



or in compounds named angiolysine. A considerable 

 numbei oi physiologically active organii phosphates 



i. in I" Idiinil in the patent literatim. ' Yeasl its II 



is considered to be a valuable loud additive. 



< )n the othei hand, there are phosphate comp Is 



thai act as poisons. One group of such compounds 

 wax discovered in 1929 l>> W. Lange, who wrote: 

 "Oi interest is the strong action of mono-fluoro- 



phosphate esters on the human bod) the effecl IS 



produced li\ \ia\ small quantities." 40 Diisopropyl 



See. e.g., ( .:' Week, vol. 77 Septi robei I, I 1 ' i5), p 7 1 ' 



l.. J. ism i i , < himu el Industri I I960), vol :'• '•. p. 252. 



1 1 W, I wi.i /.' ricl Da I Get Uschqfl 



(Berlin, 1929 . vol. 62, p. 793; vol 65 (1932 p 1598 



tluoi ophosphate has since become a pot< ntial agent 

 Idi ( I hi meal warfare. It inactivates an enzyme which 

 ils the transmission of nerve impulses t,, muscle, 

 acetylcholin esterase. 

 Organic esters oi phosphoric acids are used as 

 ti ides. | he hexa-eth) lestei oi b traphosphot i< 

 acid, prepared \>\ Gerhard Schradei \>\ heating tri- 

 ethylphosphate with phosphorus oxychloride, 4 

 ally contains tetraethylpyrophosphati I I PP 

 others. Bayer's Dipterex, the dimethyl estei oi 

 2,2,2-tru hloro-1-hydroxyethyl-phosphonate, has been 

 Red todimeth) l-2,2-dichloro\ inyl-phosph ite and 



" ( ,i nii \kii Si iik m.i k. I s pat if 1943 



(priority in Germany, 1938); S. V 1 1 \i i and M Jao 

 Industrial ■ Ei Cl try (1943), vol In. | 



I igure 22. Arthur Kornbero (b. 1 918) and Severo Ochoa b 1905) shared the 

 Nobel Prize in Medicine and Physiology in 1959. Romberg received it for resean h 

 on the biological -\ n 1 Ii<--iv ..I deoxyribonucleic acid. In particular, he found that 

 four triphosphate components and a small amount of the end product as a "tem- 

 plate" had to be present for the enzymatic synthesis Ochoa received his shari 



prize 1 search in cibonucleii acid and deoxyribonucleic acid. In particular, 



Ochoa synthesized polyribonucleotides and used the radioactive isotope, I' - tin- 

 synthetic polyribonucleotides wen- found to resemble the natural substances in all 

 essentials. 



PAPER to: HISTORY I »i I'lli )SPH( »RUS 



199 



