and Laboratory Methods. 1631 



NORMAL AND PATHOLOGICAL HISTOLOGY. 



JOSEPH H. PRATT, Harvard University Medical School. 



Books for Review and Separates of Papers on these Subjects should be Sent to Joseph H. Pratt, 

 Harvard University Medical School, Boston, Mass. 



Flexner, S. The Pathology of Bubonic Plague. Flexner gives the results of his Study 

 Univ. of Penn. Med. Bulletin, 14: 205, gf ^j^e lesions of bubonic plague as 

 I90I. . . . 



shown in material gathered in Hong 



Kong and in San Francisco. To this he adds the results of histological study 

 of experimental plague in guinea pigs and a historical review of our knowledge 

 of the disease as a whole. The article may be regarded as in part a confirma- 

 tion of the existence of true plague in San Francisco, and in part as a contribu- 

 tion to knowledge of the lesions produced by the disease in man and animals. 

 He recognizes the fact that two types of the disease exist, the bubonic and the 

 pulmonic, and points out that the former was the only form found in the San 

 Francisco outbreak. The histological changes in man are treated at length, and 

 attention is drawn to the similarity of certain cell changes with those in other 

 diseases. He emphasizes the similarity between the lesions in man and those 

 experimentally produced in animals; viz., primary bubo, necroses in liver and 

 spleen, minute cell changes, and proliferative nodules. All but the latter he con- 

 siders identical in man and animals. He suggests that further study will show 

 that the proliferative nodules in animals also have a counterpart in the human 

 lesions. W. R. Brinckerhoff. 



Herxheimer, 0. Ueber supravasale Pericard- Herxheimer studies histologically the 

 Knotchen und Sehnenflecke. Virch. Archiv. modules distributed along the epicardial 

 fur path. Anat. 165: 248, 1901. o x- 



surface of the coronary arteries in five 



cases occurring in twenty-three consecutive autopsies. These are generally lim- 

 ited to the ventricles, and occur most frequently in the region of the bifurcation 

 of the vessel. In only one case does the vein show any. In each case milk 

 patches occur. The nodules bear no relation to the adventitia of the vessel, but 

 develop from the connective tissue lying between the endothelial and elastic lay- 

 ers of the epicardium. 



They consist of dense connective tissue arranged in lamellae parallel to the 

 surface. The periphery is the most cellular portion. In some nodules there are 

 spaces lined by cubical endothelium. The nodules begin as a localized thick- 

 ening of the epicardium over an artery. Changes in the artery itself are infre- 

 quent and inconstant. Herxheimer finds no constant change in the external 

 elastic lamella such as Knox (Jour, of Exp. Med., 4 : 245) describes and regards 

 as the primary change. 



The structure and origin of these nodules, according to Herxheimer, agrees 

 with that described by Meyer and Ribbert, for milk patches, except that, in the 

 latter, spaces lined by endothelium are more frequent. Finally in his cases he 

 describes transitions between supravascular nodules and milk patches. 



