1824 Journal of Applied Microscopy 



(4) A positive reaction occurs with considerable regularity in the following 

 conditions : 



a. Infection with pyogenic organisms, either local or general. 



b. Toxemia of bacterial origin, as in diphtheria and typhoid. 



c. Non-bacterial toxemia : e. g., uremia. 



d. Disturbances of respiration. 



e. Grave anemia, both primary and secondary. 



(5) The sign is absent, in their experience, in pleurisy, rheumatism, extra- 

 uterine pregnancy, alcoholism, abcesses with free drainage, lead poisoning, early 

 malignant disease, nervous conditions, tuberculosis if uncomplicated by second- 

 ary infection, and various other diseases. w. b. s. 



Wright, J. H. A Case of Multiple Myeloma. The following interesting pathological 



Contributions to the Science of Medicine, report is given by Wright on a patient 



dedicated by his pupils to Dr. W. H. Welch. .^, i.^- i i • ^ i -.^i 



Balto., pp. 359-366, 1900. With multiple myeloma associated with 



albumosuria. Tumor masses, mostly 

 small in size, were found in the sternum, ribs, vertebrse and skull. On section 

 they appeared generally to consist of soft, mushy, red tissue, somewhat resem- 

 bling bone marrow. Microscopically these masses were composed of small cells 

 closely crowded together. Interspersed among them were rather numerous thin- 

 walled blood vessels. At first glance there seemed to be no supporting frame- 

 work, but on closer inspection a few delicate fibrillte were revealed. The cells 

 were somewhat variable in size, circular in outline and with nuclei of a round 

 or slightly oval shape. These nuclei varied in diameter, but were usually one- 

 half or two-thirds the size of the cell. They were often eccentrically placed. A 

 striking characteristic of these nuclei was the presence of a variable number of 

 intensely chromatin staining masses, of round or oval outline, continuous with 

 the nuclear membrane and projecting from it into the interior of the nucleus. 

 There was also a well marked, round globule of chromatin on the center of the 

 nucleus. Some of the cells had two nuclei and very few had three. The cyto- 

 plasm was homogenous. 



Wright thinks these cells are more closely related to plasma cells than to 

 marrow cells, although their cytoplasm did not in all cases show a marked affin- 

 ity for methylene blue. The new growth consequently could be spoken of as a 

 plasmoma. w. r. s. 



Watanabe. Versuche uber die Wirkung in die Watanabe reports the results of his 



Trachea eingefiihrter Tuberkelbacillen auf work on injecting tubercle bacilli into 



die Lunge von Kaninchen. Ziegler's Bei- ..1 . . r j >t«u 1 -n j 



trage, Bd 31, pp. 366-382, 1902. ^he trachea of dogs. They were killed 



from twelve hours to sixteen days after 

 the injection. The first injury he found was in the smallest bronchioles and in 

 the alveoli. In these places the epithelial cells were swollen and desquamated. 

 At the same time a serous exudation occurred and a migration of polynuclear 

 leucocytes. In other words, we have here an example of a catarrhal inflamma- 

 tion. The growth of connective tissue occurred secondarily and was accompa- 

 nied by a grouping together of mononuclear leucocytes. A decrease in the 

 number of polynucleur leucocytes was then observed. Giant cells appeared to 

 be formed by the fusion of several cells. w. r. s. 



