and Laboratory Methods. 1907 



positive results. He observes that in transplanting portions of the tumor the 

 greater part becomes necrotic. The morphological and physiological character 

 of the tumor is generally preserved. Certain modifications of the form, however, 

 occur under certain conditions, and it is possible to recognize some causes for 

 these variations. Variations in the character of the cells may also occur, for 

 tumors, which are typical spindle-celled sarcomata, may resemble on transplan- 

 tation endotheliomata and appear on further transplantation like their original 

 form. Tumors which have ceased to grow may increase in size after a portion 

 is excised. Local causes, as possibly the pressure of the corrective tissue cap- 

 sule, may hinder the tumor's growth. Secondary nodules are formed especially 

 near an ulcerated portion of the tumor. Metastases may occur by contact, but 

 no example was noted of metastases through the blood vessels or the lymphatics. 

 Tumor particles already infected at the time of the transplantation may still 

 cause a tumor formation. w. r. s. 



MacCallum, W. Q. A Case of Multiple Mye- The pathological features are here 

 loma. The J. of Exp. Med., Balto., 6: given of the case where clinical symp- 

 53- 3» 1901- toms, including the occurrence of 



albumosuria, had been already described by Dr. Hamburger in the Bulletin of 

 the Johns Hopkins Hospital, 1901, xii, p. 38. At the autopsy tumor masses 

 were found in the femur, ilium, clavicle, sternum and scapula, with pathological 

 fractures. There was also a tumor mass projecting from the skull. These 

 tumors were in general very soft and not sharply demarcated from the marrow 

 of the bone from which they sprung. They were usually of a deep red color 

 and showed everywhere a greyish tint. In nearly all of them definite nodules 

 of firmer consistency and greyish-white in color were found. As in Wright's 

 case, so here a delicate stroma was seen, in the rather wide meshes of which lay 

 innumerable rather large round cells. The nucleus was large, round and vesi- 

 cular, sometimes lying eccentrically. Two or three nuclei were at times found 

 in one cell. Each nucleus was provided with a nucleolus and points and strands 

 of chromatin arranged sometimes in a somewhat radial way. In dried smears, 

 stained with Ehrlich's triple stain, the nucleus showed a certain similarity be- 

 tween its staining property and that of the myelocyte's nucleus. The proto- 

 plasm presented a rather ragged and granular appearance. With the triple stain 

 it had a pale pink coloration and no specific granules were seen. With poly- 

 chrome methylene blue of Unna or alkaline methylene blue it took on only the 

 palest greenish-grey coloration. It showed nothing of the specific staining of 

 plasma cells and exceeded them greatly in size. MacCallum comes to an oppo- 

 site conclusion from Wright's and thinks these cells are derived from the large 

 non-granular forerunners of the myelocytes. w. r. s. 



